Registration Dossier
Registration Dossier
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EC number: 232-489-3 | CAS number: 8052-41-3 A colorless, refined petroleum distillate that is free from rancid or objectionable odors and that boils in a range of approximately 148.8°C to 204.4°C (300°F to 400°F).
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with adequate and reliable documentation / justification
- Justification for type of information:
- QSAR prediction: US EPA accepted QSAR method for organic chemicals properties assessment.
Data source
Reference
- Reference Type:
- other: QSAR model
- Title:
- EPI Suite v 4.1/DERMWIN v2.01
- Author:
- US EPA
- Year:
- 2 014
- Bibliographic source:
- http://epa.gov/oppt/exposure/pubs/episuite.htm
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- Using the DERMWIN v2.01 QSAR model
- GLP compliance:
- no
- Remarks:
- not applicable to QSAR models
Test material
- Reference substance name:
- Stoddard solvent
- EC Number:
- 232-489-3
- EC Name:
- Stoddard solvent
- Cas Number:
- 8052-41-3
- Molecular formula:
- C10H22
- IUPAC Name:
- stoddard solvent
- Test material form:
- liquid
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: QSAR model,
- Strain:
- other: QSAR model,
- Sex:
- not specified
Administration / exposure
- Type of coverage:
- other: QSAR model
- Vehicle:
- other: QSAR model
- Duration of exposure:
- not applicable to QSAR models
- Doses:
- not applicable to QSAR models
- No. of animals per group:
- not applicable to QSAR models
- Control animals:
- no
- Details on study design:
- not applicable to QSAR models
- Details on in vitro test system (if applicable):
- not applicable to QSAR models
Results and discussion
- Signs and symptoms of toxicity:
- not specified
- Dermal irritation:
- not specified
- Absorption in different matrices:
- A QSAR model predicts that the permeability of Stoddard solvent to human skin is quite low. The permeability coefficient was determined to be 0.00115 mg/cm2, which is around 1% of the skin penetration rate.Predicted dermally absorbed coefficient was determined to be Kp (est)=0.362 cm/hr.
Any other information on results incl. tables
A QSAR model predicts that the permeability of Stoddard solvent to human skin is quite low. The permeability coefficient was determined to be 0.00115 mg/cm2, which is around 1% of the skin penetration rate.Predicted dermally absorbed coefficient was determined to be Kp (est)=0.362 cm/hr.
Applicant's summary and conclusion
- Conclusions:
- A QSAR model predicts that the permeability of Stoddard solvent to human skin is quite low. The permeability coefficient was determined to be 0.00115 mg/cm2, which is around 1% of the skin penetration rate.Predicted dermally absorbed coefficient was determined to be Kp (est)=0.362 cm/hr.
- Executive summary:
A QSAR model predicts that the permeability of Stoddard solvent to human skin is quite low. The permeability coefficient was determined to be 0.00115 mg/cm2, which is around 1% of the skin penetration rate.Predicted dermally absorbed coefficient was determined to be Kp (est)=0.362 cm/hr.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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