Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-817-2 | CAS number: 110-94-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 19 August - 19 October 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 D (Ready Biodegradability: Closed Bottle Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Batch No.of test material: 05X034
- Expiration date of the lot/batch: Not specified
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: stored at room temperature in the dark
- Solubility and stability of the test substance in the solvent/vehicle: Soluble in deionised water
TREATMENT OF TEST MATERIAL PRIOR TO TESTING
- Final preparation of a solid: In stock solution - Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: Stromness Treatment Works, Bu Point
- Date of collection: 14 September 2016
- Initial cell/biomass concentration: 9.9 x 10^4 CFU/mL (at collection); 1.6 x 10^4 CFU/mL (on test initiation day 1)
- Water filtered: yes
- Type and size of filter used: 1 µm Whatman filter
INOCULUM PROPERTIES:
- pH: 7.00
- Temperature: 19.9 °C
- Conductivity: 1473 µS/cm
- Dissolved oxygen: 3.94% saturation
- Volume of inoculum added: 1.5 mL/L - Duration of test (contact time):
- 28 d
- Initial conc.:
- 9.02 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- O2 consumption
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Deionised water. 1 L of medium contains 1 mL of stocks A, B, C and D. (Stock A = KH2PO4 8.5 g/L; K2HPO4 21.75 g/L; Na2HPO4.2H2O 33.40 g/L; NH4Cl 0.5 g/L. Stock B = CaCl2 27.50 g/L. Stock C = MgSO4.7H2O 22.50 g/L. Stock D = FeCl3.6H2O 0.25 g/L; EDTA, Di-sodium salt 0.4 g/L).
- Test temperature: 22 ± 2 °C
- pH: Test water = pH 7.46 on collection; Inoculum = pH 7.00
- Aeration of dilution water: 20 minutes
- Continuous darkness: yes
TEST SYSTEM
- Culturing apparatus: 270-276 mL glass BOD bottles
- Number of culture flasks/concentration: 3 replicate bottles per time point for test material, oxygen blank, reference material and toxicity control
- Measuring equipment: Luminescent dissolved oxygen meter (Hach HQ40d) and probe (Hach LD010101)
SAMPLING
- Sampling frequency: 7 day intervals
CONTROL AND BLANK SYSTEM
- Inoculum blank: Measure of background oxygen consumption in test medium
- Toxicity control: Mixture of sodium benzoate and test material - Reference substance:
- benzoic acid, sodium salt
- Test performance:
- The biodegradation of the test material achieved the pass level of 60% removal of ThOD within the 10 (or 14) day window from reaching 10% biodegradation or by the test end day.
The original test was conducted in accordance with the study plan, but failed the blank oxygen consumption validity criterion. A repeat test was conducted in accordance with the study plan and met all relevant validity criteria. There were no deviation in this test. - Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 73
- Sampling time:
- 28 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 61
- Sampling time:
- 21 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 63
- Sampling time:
- 14 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 51
- Sampling time:
- 7 d
- Parameter:
- % degradation (O2 consumption)
- Value:
- 0
- Sampling time:
- 0 d
- Details on results:
- Test material percentage biodegradation: After 0 days = 0%; After 7 days = 51%; After 14 days = 63%; After 21 days = 61%; After 28 days = 73%
Test material + sodium benzoate percentage biodegradation = After 0 days = 0%; After 7 days = 58%; After 14 days = 58%; After 21 days = 64%; After 28 days = 71%
See attached background material for full results tables. - Key result
- Parameter:
- ThOD
- Value:
- 1.211 mg O2/g test mat.
- Results with reference substance:
- Sodium benzoate exhibited 84% biodegradation in 28 days
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The percentage biodegradation for glutaric acid over 28 days was found to be 73%. The registered substance can therefore be considered readily biodegradable under the conditions of this test.
- Executive summary:
The ready biodegradation of glutaric acid was analysed in a GLP study carried out according to the OECD Guideline for the Testing of Chemicals 301D 'Read biodegradability - Closed bottle method'. This procedure seeks to determine the biodegradability of an organic test material in a freshwater environment. The percentage biodegradation for the registered substance was found to be 73% over the duration of the 28 day study. The ThOD was determined as 1.211 mgO2/mg and the 28-day inhibition was found to be 8%. The validity criteria for this test were all met. Therefore, the registered substance can be considered readily biodegradable under the conditions of this test.
Reference
See attached background material for full results tables.
Description of key information
The ready biodegradation of glutaric acid was analysed in a GLP-certified key study, which was carried out according to the OECD Guideline for the Testing of Chemicals 301D 'Read biodegradability - Closed bottle method'. This procedure seeks to determine the biodegradability of an organic test material in a freshwater environment. The percentage biodegradation for the registered substance was found to be 73% over the duration of the 28-day study. The ThODNH3was determined as 1.211 mgO2/mg and the 28-day inhibition was found to be 8%. The validity criteria for this test were all met. Therefore, the registered substance can be considered readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.