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EC number: 243-349-6 | CAS number: 19819-98-8
An acute oral LD50 for females was not calculated as the data generated were not suitable to be analysed with the statistical method chosen.
In this study, 5 groups of 10 rats (5 males and 5 females) were administered Etaphen at dose levels of 1000, 1600, 2000, 2500 and 3200 mg/kg bw. Animals were observed for 14 days. None of the 10 test animals died at 1000 mg/kg, 5 out of 10 died at 1600 mg/kg, 9 out of 10 died at 2000 mg/kg, and all rats died at the 2500 and 3200 mg/kg levels. Observed clinical signs included body drop, prostration, exophthalmus, decreased activity, semi-prostration, abnormal gait, dyspnea, tremors, ataxia, ptosis, diarrhea, decreased body tone, hypersensitivity, hyperactivity and chromodacryorrhea. The acute oral LD50 for the substance in male and female rats was determined to be 1609.3 mg/kg bw with a 95% CI of 1399.6 to 1850.4 mg/kg bw and is considered harmful.
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