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Diss Factsheets
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EC number: 405-370-0 | CAS number: 6334-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Dose descriptor:
- NOAEL
- 20 mg/kg bw/day
Additional information
In a one-generation reproduction toxicity study, rats were
administered 1,000, 4,500, and 20,000 ppm (target
concentrations of 50 to 1,000 mg/kg bw/day) test compound in
the diet, beginning at approx. six weeks of age. Animals
were mated after eleven weeks of exposure and treatment
continued throughout gestation, lactation, and until
terminal necropsy. There was no treatment related mortality
observed in any of the groups. Clinical signs were limited
to soft and/or irregular feces observed in male and female
animals exposed to 20,000 ppm. Due to the delayed onset of
this effect (males: after the mating period; females: after
6-7 weeks of treatment), the significance and relation to
treatment is unclear. Reproductive toxicity was not observed
in any of the treatment groups.
Short description of key information:
N,N,N',N'-tetrakis-(2-hydroxyethyl) hexanediamide, when administered in the diet, has no observed effect level (NOEL) for gerneral toxicity in parental animals at 4500 ppm. At 20,000 ppm, indications of toxicity were limited to soft and/or irregular feces in both sexes. Due to their delayed onset, the toxicological significance and relationship to treatment of these signs were considered equivocal. Reproductive toxicity was not observed at doses up to and including 20,000 ppm.
Effects on developmental toxicity
Description of key information
No developmental toxicity/teratogenicity studies are available for N,N,N',N'-tetrakis-(2-hydroxyethyl) hexanediamide. A data waiver is claimed.
Justification for classification or non-classification
Regarding toxicity to reproduction (embryotoxicity and fertility) N,N,N',N'-tetrakis-(2-hydroxyethyl) hexanediamide is not classified according to the criteria of EC Regulation 1272/2008.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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