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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
Data is from IUCLID dataset

Data source

Reference
Reference Type:
review article or handbook
Title:
IUCLID Dataset - 2,2'-Methyliminodiethanol
Author:
EUROPEAN COMMISSION – European Chemicals Bureau
Year:
2000
Bibliographic source:
IUCLID Dataset- EUROPEAN COMMISSION – European Chemicals Bureau- 18–FEB–2000

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
Skin irritation study was conducted in rabbits for test chemical N-Methyldiethanolamine.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2'-methyliminodiethanol
EC Number:
203-312-7
EC Name:
2,2'-methyliminodiethanol
Cas Number:
105-59-9
Molecular formula:
C5H13NO2
IUPAC Name:
2,2'-(methylimino)diethanol
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report):N-Methyldiethanolamine
- Molecular formula :C5H13NO2
- Molecular weight:119.163 g/mol
- InChI:1S/C5H13NO2/c1-6(2-4-7)3-5-8/h7-8H,2-5H2,1H3
- Substance type:Organic
- Physical state:Liquid

Test animals

Species:
rabbit
Strain:
not specified
Details on test animals or test system and environmental conditions:
No data

Test system

Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Amount / concentration applied:
No data
Duration of treatment / exposure:
No data
Observation period:
No data
Number of animals:
No data
Details on study design:
No data

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: No data
Reversibility:
no data
Remarks on result:
other: Skin irritation was not observed.

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test material N-Methyldiethanolamine (CAS No: 105-59-9) was observed to be not irritating on rabbits skin.
Executive summary:

The skin irritation test was carried out in rabbits to determine the skin irritation potency of test chemical N-Methyldiethanolamine (CAS No: 105-59-9) by Draize Test.

 No known skin reactions were observed. Therefore the test chemical N-Methyldiethanolamine (CAS No: 105-59-9) can be considered as not irritating to rabbits skin.