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Toxicological information

Skin sensitisation

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Administrative data

Endpoint:
skin sensitisation: in vivo (non-LLNA)
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
secondary literature
Justification for type of information:
data is from NTRL reports

Data source

Reference
Reference Type:
secondary source
Title:
Basic toxicity of test chemical in rats and mice with cover letter dated 06/10/92
Author:
NTRL report
Year:
1992
Bibliographic source:
OTS0537531, 1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: As mentioned below
Principles of method if other than guideline:
Skin Sensitization potential of the test chemical was assessed on guinea pigs
GLP compliance:
not specified
Type of study:
other: standardized test
Justification for non-LLNA method:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
1'-acetonaphthone
EC Number:
213-384-1
EC Name:
1'-acetonaphthone
Cas Number:
941-98-0
Molecular formula:
C12H10O
IUPAC Name:
1'-acetonaphthone
Test material form:
liquid
Details on test material:
-Name of test material: 1-(1-naphthyl)ethanone
- Molecular formula: C12H10O
- Molecular weight: 170.21 g/mol
- Smiles notation: c12c(cccc1C(C)=O)cccc2
- InChl: 1S/C12H10O/c1-9(13)11-8-4-6-10-5-2-3-7-12(10)11/h2-8H,1H3
- Substance type: Organic
- Physical state: Liquid

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available.

Study design: in vivo (non-LLNA)

Induction
Route:
other: no data available
Vehicle:
not specified
Adequacy of induction:
not specified
Challenge
No.:
#1
Route:
other: No data available.
Vehicle:
not specified
Adequacy of challenge:
not specified
No. of animals per dose:
5 guinea pigs
Details on study design:
No data available.
Challenge controls:
No data available.
Positive control substance(s):
not specified

Study design: in vivo (LLNA)

Statistics:
No data available.

Results and discussion

In vivo (non-LLNA)

Results
Key result
Reading:
1st reading
Group:
test chemical
No. with + reactions:
0
Total no. in group:
5
Clinical observations:
No sensitization was observed
Remarks on result:
no indication of skin sensitisation

Applicant's summary and conclusion

Interpretation of results:
other: Not sensitizing
Conclusions:
The test chemical was not sensitizing to the skin of any of the 5 Guinea Pigs. Therefore the test chemical was considered to be not sensitizing inGuinea Pigs.
Executive summary:

Skin sensitization study was conducted on 5 Guinea Pigs for the test chemical. The test chemical was not sensitizing to the skin of any of the 5 Guinea Pigs. Therefore the test chemical was considered to be not sensitizing inGuinea Pigs.

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