1'-acetonaphthone

Short-term toxicity to aquatic invertebrates

Link to relevant study record(s)

Reference

Endpoint:

short-term toxicity to aquatic invertebrates

Type of information:

calculation (if not (Q)SAR)

Remarks:

Migrated phrase: estimated by calculation

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Data is from computational model developed by USEPA

Justification for type of information:

Data is from computational model developed by USEPA

Qualifier:

according to guideline

Guideline:

other: Modeling database

Principles of method if other than guideline:

ECOSAR v1.1

GLP compliance:

no

Analytical monitoring:

not specified

Test organisms (species):

Daphnia magna

Test type:

not specified

Water media type:

not specified

Total exposure duration:

48 h

Reference substance (positive control):

not specified

Duration:

48 h

Dose descriptor:

EC50

Effect conc.:

14.82 mg/L

Nominal / measured:

estimated

Conc. based on:

test mat.

Basis for effect:

mobility

Remarks on result:

other: Neutral Organics SAR (Baseline Toxicity)

Validity criteria fulfilled:

not specified

Conclusions:

The estimated EC50 values for aquatic invertebrate after 48 hours was 14.820 mg/l on the basis of growth rate.

Executive summary:

The short-term toxicity of the test substance to aquatic invertebrate is predicted using EPI Suite ECOSAR version 1.10. On the basis of effects observed in a static freshwater system during a 48 hr exposure, the effect concentration (EC50) for the substance is estimated to be  14.820 mg/L. Based on this value, it can be concluded that the test chemical can be considered as toxic to green algae at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 3 as per the CLP classification criteria.

 

Description of key information

Short term toxicity to aquatic invertebrate:

The short-term toxicity of the test substance to aquatic invertebrate is predicted using EPI Suite ECOSAR version 1.10. On the basis of effects observed in a static freshwater system during a 48 hr exposure, the effect concentration (EC50) for the substance is estimated to be  14.820 mg/L. Based on this value, it can be concluded that the test chemical can be considered as toxic to green algae at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 3 as per the CLP classification criteria.

 

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates

Effect concentration:

14.82 mg/L

Additional information

Short term toxicity to aquatic invertebrate:

The short term toxicity of test material on aquatic invertebrate was evaluated based on the predicted data for test chemical along with data for study reports of structurally similar read across substances.

In the predication , the short-term toxicity of the test substance to aquatic invertebrate is predicted using EPI Suite ECOSAR version 1.10. On the basis of effects observed in a static freshwater system during a 48 hr exposure, the effect concentration (EC50) for the substance is estimated to be  14.820 mg/L. Based on this value, it can be concluded that the test chemical can be considered as toxic to green algae at environmentally relevant concentrations and can be considered to be classified in aquatic chronic 3 as per the CLP classification criteria.

The above prediction was supported by data of structurally similar read across substance , determination of the inhibition of the mobility of daphnids was carried out with the substance Methyl 2-naphthyl ether according to OECD Guideline 202. The stock solution (200 g/L) was prepared by dissolving white powder in DMSO. Test solutions of required concentrations were prepared by mixing the stock solution of the test sample with reconstituted test water. The test substance was tested at the concentrations 0, 5, 10, 20, 30, 40, 80 mg/L and the immobilisation effects were observed for 48 hours. Effects on immobilisation were observed for 48 hours. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. The median effective concentration (EC50) for the test substance, in Daphnia magna was determined to be 26 mg/L on the basis of mobiity inhibition effects in a 48 hour study. This value indicates that the substance is likely to be hazardous to aquatic invertebrates can can be classified as Aquatic chronic category 3 as per the CLP criteria.

 

For another structurally similar read across substance , aim of this study was to assess the short term toxicity of test material to aquatic invertebrates daphnia magna. Study was performed according to the OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test) in a static system for the total exposure period of 48 hrs.

 The stock solution 100 g/l was prepared by dissolving white powder in acetone. Test solutions of required concentrationas were prepared by mixing the stock solution of the test sample with reconstituted test water.1.2 , 2.5 , 5.0 , 10.0 , 20.0 , 40.0 mg/lconcentrations were used in the study. Effects on immobilisation were observed for 48 hours. With the test substance one positive control Potassium dichromate (K2Cr2O7) was also run simultaneously. After the exposure of chemical, effect concentration EC50 was calculated using nonlinear regression by the software Prism 4.0. The median effective concentration (EC50) for the test substance , in Daphnia magna was determined to be 48.1 mg/L on the basis of mobility inhibition effects in a 48 hour study. Based on the EC50 value, substance is likely to be hazardous to aquatic invertebrate can be classified as aquatic chronic 3 category as per the CLP classification criteria.