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EC number: 619-383-6 | CAS number: 98967-40-9
XRD-498 was evaluated for genetic activity in the Ames' test with and without the addition of a mammalian metabolic activation preparation using a pre-incubation assay. The studies were conducted using Salmonella typhimurium bacterial tester strains TA98, TA100, TA1535, TA1537, and TA1538. XRD-498 was tested at amounts of 0.01, 0.0316, 0.1, 0.316, and 1.0 mg per plate and was observed to be toxic (reduced growth on plates) to all strains at 1.0 mg per plate with or without the mammalian metabolic activation preparation and at 0.316 mg per plate without activation in all strains except TA1538. XRD-498 was not mutagenic to any of the bacterial tester strains, with or without metabolic activation, indicating a lack of genotoxic activity under the conditions of the present study.
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