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Administrative data

Key value for chemical safety assessment

Additional information

All four of the studies addressed different aspects of genetic toxicity. All were performed in accordance with recognised EPA guidelines and to GLP standard. All of the studies were considered reliable enough to be key.

No evidence of genetic toxicity was seen in any of the available studies.


Short description of key information:
Three in-vitro genetic toxicity studies are available:
Mendrala AL (1988b): Bacterial reverse mutation assay (AMES): Negative
Linscombe VA & Gollapudi BB (1988): Mammalian cell gene mutation assay: Negative
Mendrala AL (1988a): Unscheduled DNA Synthesis (UDS) assay: Negative

On in-vivo genetic toxicity study is available:
McClintock ML & Gollapudi BB (1988): In-vivo cytogenicity: Negative

Endpoint Conclusion: No adverse effect observed (negative)

Justification for classification or non-classification

With reference to the information available on this substance, no classification for genetic toxicity is required in accordance with Directive 67/548/EEC or Regulation (EC) No. 1272/2008.