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EC number: 619-383-6 | CAS number: 98967-40-9
XRD-498 was evaluated for acute oral toxicity in Fischer 344 rats. Five rats per sex recieved 5000 mg/kg of XRD-498 by single dose gavage. Parameters examined during the two week observation period included body weights and in-life clinical observations. All animals were examined for gross pathologic observations. All animals survived the 5000 mg/kg limit test established by the guidelines and therefore no other dose level was tested. All animals were in apparent good health throughout the study termination. There were no gross pathologic changes in any of the rats at necropsy. Under the conditions of this study, the acute oral LD50 or XRD-498 was greater than 5000 mg/kg. Based on these results, the acute oral toxicity of XRD-498 was categorized as extremely low.
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