Registration Dossier

Administrative data

Description of key information

Three acute toxicity studies are available for Flumetsulam: an acute oral toxicity study on rats (Mizell MJ, Schuetz DJ & Eisenbrandt DL (1988)), an acute inhalation toxicity study on rats (Nitschke KD, Bradley GJ, Schuetz DJ & Crissman JW (1990)) and an acute dermal toxicity study on rabbits (Mizell MJ, Schuetz DJ & Johnson KA (1988)). 
The acute oral LD50 of Flumetsulam was found to be greater than 5000 mg/kg.
The acute inhalation LC50 of Flumetsulam was found to be greater than 1.2 mg/L, which was the maximum achievable concentration in air.
The acute dermal LD50 of Flumetsulam was found to be greater than 2000 mg/kg bw.

Key value for chemical safety assessment

Additional information

All studies were reliable EPA guideline studies performed to GLP standard. All were considered robust enough to be key. No signs of toxicity were observed up to the concentrations tested.

Justification for classification or non-classification

With reference to the information available on this substance, no classification for acute toxicity is required in accordance with Directive 67/548/EEC or Regulation (EC) No. 1272/2008.