Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is form per- reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Monographs on Fragrance Raw Materials: Geranyl Isobutyrate
Author:
D. L. J. Opdyke
Year:
1975
Bibliographic source:
Food Cosmet. Toxicol. Vol. 13. pp. 449-457.1975

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of 3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate in rat
GLP compliance:
not specified
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
Geranyl isobutyrate
EC Number:
219-062-7
EC Name:
Geranyl isobutyrate
Cas Number:
2345-26-8
Molecular formula:
C14H24O2
IUPAC Name:
geranyl isobutyrate
Details on test material:
SMILES:CC(C)C(=O)OCC=C(C)CCC=C(C)C
Specific details on test material used for the study:
- Name of test material (as cited in study report): Geranyl isobutyrate (3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate)
- Molecular formula (if other than submission substance): C14H24O2
- Molecular weight (if other than submission substance): 224.342g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals or test system and environmental conditions:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
not specified
Doses:
5000 mg/kg
No. of animals per sex per dose:
not specified
Control animals:
not specified
Details on study design:
not specified
Statistics:
not specified

Results and discussion

Preliminary study:
not specified
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 5 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: No mortality observed
Mortality:
No mortality was observed in treated rat at 5000 mg/kg
Clinical signs:
other: not specified
Gross pathology:
not specified
Other findings:
not specified

Applicant's summary and conclusion

Interpretation of results:
Category 5 based on GHS criteria
Conclusions:
LD50 was considered to be > 5000 mg/kg bw when rat were treated with 3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate orally.
Executive summary:

In a acute oral toxicity study, rat were treated with 3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate in the concentration of 5000 mg/kg bw orally. No mortality was observed in treated rat at 5000 mg/kg. Therefore, LD50 was considered to be > 5000 mg/kg bw when rat were treated with 3,7-dimethylocta-2,6-dien-1-yl 2-methylpropanoate orally.