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EC number: 944-572-8 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
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- Nanomaterial pour density
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- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
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- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessment supported with ToxRTool (Schneider, K. et al. "ToxRTool", a new tool to assess the reliability of toxicological data. Toxicol Lett. 2009 Sep 10:189(2):138-44)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Qualifier:
- according to guideline
- Guideline:
- other: 16 CFR 1500.3
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 5-(C11-C12 alkyl, branched)-2-hydroxy-benzaldehyde oxime
- EC Number:
- 944-572-8
- Molecular formula:
- C18H29NO2 - C19H31NO2 (main constituents)
- IUPAC Name:
- 5-(C11-C12 alkyl, branched)-2-hydroxy-benzaldehyde oxime
- Details on test material:
- - Name of test material (as cited in study report): RD 5893; Dodecylsalicylaldoxime
- Physical state: dark yellow, semi-solid viscous liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- 0.5, 0.89, 1.58, 2.81 and 5.0 g/kg b.w.
- No. of animals per sex per dose:
- 5
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 1 220 mg/kg bw
- 95% CL:
- >= 1 060 - <= 1 410
- Mortality:
- Dose [g/kg] mortality
0.50 0/10
0.89 2/10
1.58 7/10
2.81 10/10
5.00 10/10 - Clinical signs:
- For all concentrations salivation, decreased activity, ataxia, bloody nasal discharge, diarrhoea were observed to a varoius degree
- Body weight:
- Body weight increase of surviving rats was normal.
- Gross pathology:
- Necropsy was performed in all rats that died during the study.
Lungs: pale and mottled
Spleen: pale and in the two highest concentration granular or dark in some rats
Kidney: pale and in the two highest concentration mottled or dark in some rats
Intestine: contains yellow (viscous) liquid; vascularised
Gastrointestinal tract: contains yellow (viscous) liquid; vascularised (higest concentration only)
Liver: dark in a few rats in the two highest concetrations - Other findings:
- none stated
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- With an LD50 of 1220 mg/kg bodyweight, the test substance is considered as acute toxic Category 4.
- Executive summary:
The test substance was assessed for its acute oral toxicity using the OECD 401 protocol. Four dose levels between 0.5 and 5 g/kg bw were applied to SD rats and a control group receiving the vehicle was assigned. 5 male and 5 female animals were assigned to each dose group. The LD50 was determined to be 1220 mg/kg bodyweight using a linear regression model. The test substance is assigned to acute toxic Category 4.
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