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Toxicological information

Specific investigations: other studies

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Administrative data

Endpoint:
endocrine system modulation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: recent study conducted according to reliable in-house protocol

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2013
Report date:
2013

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: according to P. Sohoni and J.P. Sumpter (1998)
Principles of method if other than guideline:
The aim of the study was to determine the androgenic and antiandrogenic potential of Benzaldehyde, dodecylhydroxy-, oxime, branched (solvent-free and dodecylphenol-depleted). The yeast cells used in the yeast androgen screening (YAS) assay have been stably transformed with genes for the human androgen receptor and the ß-galactosidase reporter gene. Androgenic as weil as antiandrogenic potentials of the test substances mediated by receptor binding or blocking can be determined using this assay, respectively.
GLP compliance:
no
Type of method:
in vitro

Test material

Constituent 1
Chemical structure
Reference substance name:
5-(C11-C12 alkyl, branched)-2-hydroxy-benzaldehyde oxime
EC Number:
944-572-8
Molecular formula:
C18H29NO2 - C19H31NO2 (main constituents)
IUPAC Name:
5-(C11-C12 alkyl, branched)-2-hydroxy-benzaldehyde oxime
Details on test material:
- Name of test material: Benzaldehyde, dodecylhydroxy-, oxime, branched (solvent-free and dodecylphenol-depleted)
- Physical state: Liquid, highly viscous, golden brown
- Analytical purity: >99%
- Storage condition of test material: Room temperature

Test animals

Species:
other: yeast

Administration / exposure

Vehicle:
DMSO
Doses / concentrations
Remarks:
Doses / Concentrations:

Basis:

Results and discussion

Details on results:
ln this study, the test substance Benzaldehyde, dodecylhydroxy-, oxime, branched (solvent-free and dodecylphenol-depleted) showed no androgenic activity in comparison to dihydrotestosterone.
ln this study, the test substance Benzaldehyde, dodecylhydroxy-, oxime, branched (solvent-free and dodecylphenol-depleted) showed no antiandrogenic activity in comparison to hydroxyflutamide.
No cytotoxicity was observed.

Applicant's summary and conclusion