Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 216-381-3 | CAS number: 1570-64-5
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Taken from EU Risk Assessment Report - Reviewed by the Danish Environmental Protection Agency. Guideline Study.
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-chloro-o-cresol
- EC Number:
- 216-381-3
- EC Name:
- 4-chloro-o-cresol
- Cas Number:
- 1570-64-5
- Molecular formula:
- C7H7ClO
- IUPAC Name:
- 4-chloro-2-methylphenol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing: Individual
- Diet (e.g. ad libitum): Conventional laboratory diet
- Water (e.g. ad libitum): ad libitum
- Acclimation period:24 hours
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C +/- 3°C
- Humidity (%): 30-70%
- Air changes (per hr): not specified
- Photoperiod (hrs dark / hrs light): 12 hours light/ 12 hours dark
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- other:
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
0.5g of 4-Chloro-o-cresol in 0.1ml of oleum arachidis
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- Not specified
- Number of animals:
- Six female rabbits
- Details on study design:
- TEST SITE
- Area of exposure: Dorsal area of the trunk.
- Type of wrap if used: Gauze patch.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): 4 hours after start of exposure the residudal test substance was removed using water or an appropriate solvent.
SCORING SYSTEM: Primary Irritation Index
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 4 hours
- Score:
- ca. 8
- Max. score:
- 8
- Reversibility:
- not reversible
Applicant's summary and conclusion
- Interpretation of results:
- other: highly corrosive
- Remarks:
- Criteria used for interpretation of results: other: Approved clasification and Labelling Guide (Sixth Edition), Chemicals (Hazard Information and Packaging for Supply) Regulations 2009 (CHIP 4)
- Conclusions:
- Based on the results from the Scantox study 4-Chloro-o-cresol is classified as highly corrosive.
- Executive summary:
In a guideline study 6 female rabbits were dermally exposed to 0.5g PCOC in 0.1ml of oleum arachidis. The test site was covered for a period of 4 hours following which the residual test substance was removed by washing.
A primary irritation index of 8.0 was calculated. Immediately after removal of the test substance the skin was white, a sign of initial necrosis.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
