Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 903-139-3 | CAS number: -
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- A read-across justification is provided in the IUCLID chapter "assessment reports"
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Induction of human skin sensitization to ethanol
- Author:
- Stotts J and Ely WJ
- Year:
- 1 977
- Bibliographic source:
- Journal of Investigative Dermatology, 69, 219-222
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- RIFM
- Year:
- 2 009
- Bibliographic source:
- RIFM database
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- case report
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rechallenge of 2 patients
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Pentan-1-ol
- EC Number:
- 200-752-1
- EC Name:
- Pentan-1-ol
- Cas Number:
- 71-41-0
- Molecular formula:
- C5H12O
- IUPAC Name:
- pentan-1-ol
- Details on test material:
- - Name of test material (as cited in study report): 1-pentanol
Constituent 1
Method
- Type of population:
- general
- Subjects:
- - Number of subjects exposed: 2
- Clinical history:
- - History of allergy or casuistics for study subject or populations: one sensitized during a human patch test to ethanol; one to acetaldehyde during a dose range finder for a non-irritant concentration
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- RESULT OF CASE REPORT:
Positive reactions to pentanol were observed in both subjects after testing with 10% (subject 1) and 20% (subject 2) pentanol. Both reacted also to ethanol, propanol, 2-propanol, and acetaldehyde.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
