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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Adequacy of study:
other information

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
2013

Materials and methods

Test animals

Species:
rat

Administration / exposure

Duration of exposure:
4 h

Results and discussion

Effect levels
Dose descriptor:
LC50
Effect level:
>= 15.68 mg/L air
Exp. duration:
14 d
Remarks on result:
other: Greenough et al. 1981
Clinical signs:
other: Excessive grooming in surviving animals led to persistent poor coat condition throughout the study. Macroscopy of the lungs revealed the following anomalies: white foci in all lobes in one male and one female rat at 15.68 mg/L, dark red regions in two fem

Applicant's summary and conclusion

Executive summary:

In a GLP-compliant study by Greenough et al. (1981*), the inhalation LC50 in rats was estimated to be ≥15.68 mg/L/4h. SD rats (5/sex/dose) were exposed to 12.45, 15.68 and 16.27 mg DBP/L of air for four hours, and observed for 14 days. Controls were air exposed. The respirable fraction was 64.4 %, 56.9 %, and 59.9 %, respectively. A reduction in respiratory rate was seen at 15.68 mg/L. Excessive grooming in surviving animals led to persistent poor coat condition throughout the study. Macroscopy of the lungs revealed the following anomalies: white foci in all lobes in one male and one female rat at 15.68 mg/L, dark red regions in two female rats at 12.45 mg/L, and one male and one female rat at 16.27 mg/L. 6.2.2 Skin,