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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
data is from authoritative database

Data source

Reference
Reference Type:
other: Authoritative database
Title:
GESTIS for CAS: 108-69-0
Author:
Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) GESTIS-database on hazardous substance
Year:
2016
Bibliographic source:
GESTIS for CAS: 108-69-0; Institut für Arbeitsschutz der Deutschen Gesetzlichen Unfallversicherung (IFA) GESTIS-database on hazardous substance, 2016

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Principles of method if other than guideline:
To assess the eye irritation potential of 3,5-xylidine in rabbits according to a standardized rabbit eye test (OECD 405)
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material (as cited in study report): 3,5 Dimethylaniline
- Molecular formula : C8H11N
- Molecular weight : 121.182 g/mol
- Smiles notation : c1(cc(cc(c1)N)C)C
- InChl : 1S/C8H11N/c1-6-3-7(2)5-8(9)4-6/h3-5H,9H2,1-2H3
- Substance type: Organic
- Physical state: liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 3,5 Dimethylaniline
- Molecular formula : C8H11N
- Molecular weight : 121.182 g/mol
- Smiles notation : c1(cc(cc(c1)N)C)C
- InChl : 1S/C8H11N/c1-6-3-7(2)5-8(9)4-6/h3-5H,9H2,1-2H3
- Substance type: Organic
- Physical state: liquid

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
no data available

Test system

Vehicle:
unchanged (no vehicle)
Controls:
not specified
Amount / concentration applied:
undiluted
Duration of treatment / exposure:
no data available
Observation period (in vivo):
no data available
Duration of post- treatment incubation (in vitro):
no data available
Number of animals or in vitro replicates:
no data available
Details on study design:
no data available

Results and discussion

Other effects / acceptance of results:
no data available
Results of in vivo study
Irritation parameter:
overall irritation score
Basis:
mean
Time point:
other: no data available
Score:
0
Reversibility:
not specified
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
no irritation observed

Applicant's summary and conclusion

Interpretation of results:
other: not irritating
Conclusions:
In a standardized rabbit eye test (OECD 405), the undiluted 3,5-xylidine caused only slight eye irritation, which can be considered as not irritating.

Executive summary:

An eye irritation study was performed to assess the irritation potential of 3,5-xylidine in rabbits. The study was performed according toa standardized rabbit eye test (OECD 405). Undiluted 3,5-xylidine was instilled into rabbit eyes and effects were observed (duration not mentioned).

Undiluted 3,5-xylidine caused only slight eye irritation, which can be considered as not irritating.