Registration Dossier

Administrative data

Description of key information

There was no evidence of irritation when tetrakis(triphenylphosphine) palladium was applied to the intact skin of three rabbits using a 4-hour occluded patch (Zechel, 1989a).
An in vivo eye irritation test using three rabbits resulted in only transient mild irritation, not sufficient to meet the criteria for classification as an eye irritant (Zechel, 1989b).
No relevant respiratory tract data were identified.

Key value for chemical safety assessment

Skin irritation / corrosion

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Eye irritation

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No relevant irritation/corrosion human data were identified.

 

There is no indication that tetrakis(triphenylphosphine) palladium is likely to cause significant irritation to the skin or eyes. When applied to the intact skin of three rabbits using a 4-hour occluded patch, no irritation was seen. Animals were observed 1, 24, 48 and 72 hours following removal of the patch (Zechel, 1989a).

 

In an in vivo eye irritation test, tetrakis(triphenylphosphine) palladium was placed into one eye of each of three rabbits, with examination at 1, 24, 48 and 72 hours, and daily until 6 days, following application. No signs of irritation were seen in the cornea or iris. Slight irritation in the conjunctiva had completely disappeared by day 4 of observation (Zechel, 1989b).

 

No respiratory tract data were identified. A new study was not conducted as it is not a REACH Standard Information Requirement.


Justification for selection of skin irritation / corrosion endpoint:
OECD guideline study, and the only skin irritation study available.

Justification for selection of eye irritation endpoint:
OECD guideline study, and the only eye irritation study available.

Justification for classification or non-classification

Available in vivo assays gave results that failed to meet the criteria for classification for skin or eye irritation according to EU CLP criteria (EC 1272/2008).