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EC number: 238-086-9 | CAS number: 14221-01-3
There was no evidence of irritation when tetrakis(triphenylphosphine) palladium was applied to the intact skin of three rabbits using a 4-hour occluded patch (Zechel, 1989a).An in vivo eye irritation test using three rabbits resulted in only transient mild irritation, not sufficient to meet the criteria for classification as an eye irritant (Zechel, 1989b). No relevant respiratory tract data were identified.
The skin irritant potential of tetrakis(triphenylphosphine) palladium was assessed in a study conducted according to OECD Test Guideline 404 and to GLP.
No irritation was observed when 0.5 g of the test substance, moistened with water, was applied as a 4 hour occluded patch to the intact skin of three female White Russian (albino) rabbits, and observed at 1, 24, 48 and 72 hours following removal of the patch. The primary dermal irritation index was 0.
No skin classification, according to EU CLP criteria (EC 1272/2008), is required on the basis of this study.
The eye irritation potential of tetrakis(triphenylphosphine) palladium was determined in an OECD Test Guideline 405 study, conducted to GLP. The test substance (0.06 g, equivalent to 0.1 mL) was placed in the conjunctival sac of one eye, which was briefly held closed, in three female White Russian rabbits. The treated eye was not rinsed. The untreated eye in each case served as the control. The eyes were examined 1, 24, 48 and 72 hr following the application, then daily until 6 days post application.
No signs of irritation were observed on the cornea or iris. Hyperemia or crimson discolouration, slight or obvious swelling with partial eversion of lids was seen in the conjunctiva. There was also slight discharge or discharge with moistening of considerable parts around the eyes. The findings had completely disappeared at day 4 of observation. The primary irritation index was calculated as 6 (out of a possible 110).
Based on the results of this study, tetrakis(triphenylphosphine) palladium should not be classified for eye irritation according to EU CLP criteria (EC 1272/2008).
No relevant irritation/corrosion human data were identified.
There is no indication that tetrakis(triphenylphosphine) palladium is likely to cause significant irritation to the skin or eyes. When applied to the intact skin of three rabbits using a 4-hour occluded patch, no irritation was seen. Animals were observed 1, 24, 48 and 72 hours following removal of the patch (Zechel, 1989a).
In an in vivo eye irritation test, tetrakis(triphenylphosphine) palladium was placed into one eye of each of three rabbits, with examination at 1, 24, 48 and 72 hours, and daily until 6 days, following application. No signs of irritation were seen in the cornea or iris. Slight irritation in the conjunctiva had completely disappeared by day 4 of observation (Zechel, 1989b).
No respiratory tract data were identified. A new study was not conducted as it is not a REACH Standard Information Requirement.
Available in vivo assays gave results that failed to meet the criteria for classification for skin or eye irritation according to EU CLP criteria (EC 1272/2008).
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