Registration Dossier
Registration Dossier
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EC number: 211-279-5 | CAS number: 637-12-7
Endpoint summary
Administrative data
Description of key information
Bioaccumulation: aquatic / sediment:
From BCFBAF (v3.00) model of EPI suite, the estimated bio concentration factor (BCF) for Aluminum trioctadecanoate is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000.Thus it is concluded that chemical Aluminum trioctadecanoate is not expected to be bioaccumulative in fish and the food chain.
Additional information
Bioaccumulation: aquatic / sediment:
Three studies including predicted data from validated model and experimental results from authorative data source for bioaccumulation (BCF) endpoint of test substance Aluminum trioctadecanoate (Cas no. 637-12-7) with relevant read across which is structurally similar to target were summarized as follows:
First study from BCFBAF (v3.00) model of EPI suite indicate the estimated bio concentration factor (BCF) for Aluminum trioctadecanoate is 3.162 L/kg wet-wt which does not exceed the bioconcentration threshold of 2000. Thus it is concluded that chemical Aluminum trioctadecanoate is not expected to be bioaccumulative in fish and the food chain.
Above target prediction supported by experimental result of read across chemical Dibutyltin dilaurate (Cas no. 77-58-7) which suggest Bioaccumulation test was conducted for 8 weeks for determination the bioconcentration factor (BCF) and lipid content of substance Dibutyltin dilaurate (Cas no. 77-58-7) on test organism Cyprinus carpio. The recovery ratio is given- Test water: 85.9 %, Fish: 73.5 %, And Nominal concentrations used in the study as - 1st Concentration area: 2.5 microg/L,2nd Concentration area: 0.25 microg/L and Range finding study was carried out on Rice fish (Oryzias latipes) and the 48 hr LC50 value was found to be >= 0.5 mg/L. By analytical methods, the limit of detection was found to be- Test water: 1st concentration area: 0.34 ng/mL, 2nd concentration area: 0.034 ng/mL,Fish : 2.6 ng/g. Whereas the lipid content at the start and end of exposure was found to be 4%. Thus according to static Fish Test the BCF value for test substance Dibutyltin dilaurate (Cas no. 77-58-7) was observed to be 2.2<= 40 L/kg at dose concentration 2.5 microg/L and 13 <= 110 L/kg at dose concentration 0.25 microg/L on test organism Cyprinus carpio during 8 weeks period. These values indicate that the substance is not bioaccumulative in fish and food chain.(J-CHECK database;2017)
One more study from another data source for same read across i.e Dibutyltin dilaurate (Cas no. 77-58-7) indicate the observed BCF for dibutyltin dilaurate in round crucian carp (Carassius carassius grandoculis) muscle, vertebra, liver, and kidney tissue were 31, 54, 813, and 138, respectively these BCF values suggests bioconcentration in aquatic organisms is low.(HSDB database;2017)
Thus all above available values for bioaccumulation (BCF) is in the range of 2.2 to 813 (L/kg or dimensionless) which gives the final conclusion as target substance Aluminum trioctadecanoate (Cas no. 637-12-7) is non Bioaccumulative in aquatic environment.
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