Potassium phenylacetate

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, however not sufficient for C & L as only two parameters were obsersed at 72 hr.

Data source

Reference

Reference Type:

publication

Title:

Comparative studies on the irritancy of oils and synthetic perfumes to the skin of rabbits, guinea pigs, rat, miniature swine and man.

Author:

Mototoshi K, Toyoshima Y, Sato M, Yoshimura M

Year:

1979

Bibliographic source:

Cosmetics and Toiletries.94(8).41-43

Materials and methods

Principles of method if other than guideline:

From a large number of cosmetic raw materials, 39 test compounds (19 oils and 20 synthetic perfumes (which include Phenylethyl alcohol) were chosen to perform irritancy potential in Japan.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Phenyl ethyl alcohol

IUPAC Name:

Phenyl ethyl alcohol

Details on test material:

- Analytical purity:> 98%

Test animals

Species:

rabbit

Strain:

Angora

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Housing:Animals were maintained in individual stainless steel cages
- Weight at study initiation:2.3 to 3.0 kg (average weight 2.6 kg)
- Diet (e.g. ad libitum):Food were permitted
- Water (e.g. ad libitum):Water were permitted

Test system

Type of coverage:

occlusive

Preparation of test site:

shaved

Vehicle:

not specified

Controls:

other: Yes. Hexadecane was reagent grade and used as a control

Amount / concentration applied:

TEST MATERIAL
- Amount(s) applied :0.1 g of 100% test compound

Duration of treatment / exposure:

24 hours then second exposure for 30 min.

Observation period:

24 hr and at 72 hr

Number of animals:

6 animals in the treatment group and the control

Details on study design:

TEST SITE
- Area of exposure:The hair on a area of the dorsal surface of each animal was clipped as close to the skin as possible using an electric clipper.The test areas measured 3 x 3 cm and were approximately 2 cm apart
- Type of wrap if used:A 25 cm diameter plastic collar was wrapped around the neck of each rabbit


SCORING SYSTEM: See table 1 for details

Results and discussion

In vivo

Results

Irritation parameter:

primary dermal irritation index (PDII)

Basis:

mean

Time point:

other: 72 h

Score:

2

Reversibility:

no data

Remarks on result:

other: measurements only made at 72 hours

Any other information on results incl. tables

The dilating rate of blood vessels, the swelling rate (edema), the bluing rate (as a result of increased capillary permeability), and the bleeding rate on the test sites were read using transmitting light. The total score of the averages of the reddening rate ( erythema, 72 hr reading), the dilating rate, the swelling rate, and the bluing rate for 6 animals in a group was referred to as the primary irritation index.

Table 2. Relative irritancy of 100 and 32 % concentrations of test compounds (synthetic perfumes) in the skin of rabbit

Compound	Rabbit (100%)
Phenyl ethyl alcohol	2

Scoring : 0 = negative, 1= mildly irritating, 2= moderately irritating, 3= severely irritating

Applicant's summary and conclusion

Interpretation of results:

moderately irritating

Remarks:

Migrated information Criteria used for interpretation of results: other: See any other information on f materials and methods iclu.tables

Conclusions:

Phenyl ethyl alcohol was concluded as moderately irritant.