Registration Dossier

Administrative data

Description of key information

According to a brief summary in an Expert Group report (DECOS, 2008) of a 40-year-old study, male Sprague-Dawley rats received platinum(IV) oxide in the diet at a level corresponding to a dose of about 815 mg/kg bw/day for 4 weeks. No effect on growth was apparent (Holbrook, 1976; Holbrook et al., 1976). Marginal effects on a small number of clinical chemistry parameters [likely including aniline hydroxylase and cytochrome b5 activity] were noted following such treatment (Holbrook et al., 1976).

Key value for chemical safety assessment

Repeated dose toxicity: via oral route - systemic effects

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Repeated dose toxicity: inhalation - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: inhalation - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - systemic effects

Endpoint conclusion
Endpoint conclusion:
no study available

Repeated dose toxicity: dermal - local effects

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

According to a brief summary in an Expert Group report (DECOS, 2008) of a 40-year-old study, male Sprague-Dawley rats received platinum(IV) oxide in the diet at a level corresponding to a dose of about 815 mg/kg bw/day for 4 weeks. No effect on growth was apparent (Holbrook, 1976; Holbrook et al., 1976). Marginal effects on a small number of clinical chemistry parameters [likely including aniline hydroxylase and cytochrome b5 activity] were noted following such treatment (Holbrook et al., 1976).

 

 

References (not included elsewhere in this IUCLID dossier)

DECOS (2008). Dutch Expert Committee on Occupational Standards. Platinum and Platinum Compounds. Health-based recommended occupational exposure limit. Gezondheidsraad, 2008/12OSH.https://www.gezondheidsraad.nl/en/publications/gezonde-arbeidsomstandigheden/platinum-and-platinum-compounds-health-based-recommended

 

Holbrook DJ (1976). Assessment of toxicity of automotive metallic emissions. vol 1: Assessment of fuel additives emission toxicity via selected assays of nucleic and protein synthesis, Research Triangle Park, North Carolina, US Environmental Protection Agency, Office of Research and Development, Health Effects Research Laboratories, 67 pp (EPA/600/1-76/010a) [cited in DECOS, 2008].

 

Holbrook DJ et al. (1976). Effects of platinum and palladium salts on parameters of drug metabolism in rat liver. J Toxicol Environ Health 1:1067-1079 [cited in DECOS, 2008].

Justification for classification or non-classification

No evidence of specific target organ toxicity was noted in the limited repeated dose studies identified. As such, classification for STOT-RE is not considered appropriate.