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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
not stated in paper, but submitted for publication in 1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Although the study is not conducted to a modern protocol and is somewhat limited, it is nevertheless fairly well documented and scientifically acceptable

Data source

Reference
Reference Type:
publication
Title:
Dermal irritancy of metal compounds. Studies with palladium, platinum, lead, and manganese compounds
Author:
Campbell KI et al.
Year:
1975
Bibliographic source:
Archives of Environmental Health, 30, 168-170

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Dermal irritancy asessed using male albino rabbits using procedures and evaluation criteria adopted from those in use by the National Institute for Occupational Safety and Health, ... a modification of the official Food and Drug Administration procedure [1973]"
GLP compliance:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
Platinum dioxide
CAS# 1314-15-4

Test animals

Species:
rabbit
Strain:
other: albino
Details on test animals and environmental conditions:
no data

Test system

Type of coverage:
occlusive
Preparation of test site:
other: Pairs of test sites, each 2 cm x 2 cm, on the closely clipped dorsolaterals aspects of each animal, one side abraded and the other side intact
Vehicle:
water
Remarks:
0.1 ml
Controls:
yes, concurrent vehicle
Amount / concentration applied:
0.1 g
Duration of treatment / exposure:
24 hours
Observation period:
skin reactions scored immediately on removal of patch and 48 hours later
Number of animals:
Total of 6 rabbits, with up to 7 pairs of test sites each, used to test 14 test substances, some substances tested more than once
Details on study design:
Pairs of test sites, each 2 cm x 2 cm, on the closely clipped dorsolaterals aspects of each animal, one side abraded and the other side intact; Test substances in solid (powder) state were mixed with water (0.1 g quantity mixed with 0.1 ml deionised water) and spread over each site; after application of test substances [several probably tested simultaneously on each animal], test sites occluded; 24 hours later, coverings removed and test sites gently washed with soap, rinsed and dried; skin reactions scored immediately and 48 hours later; evaluation on a grading scale from 0 to 4 [similar to Draize scale]

Results and discussion

In vivo

Results
Irritation parameter:
overall irritation score
Basis:
mean
Remarks:
single test rating or average of two or three
Time point:
other: 24 and 72 hours
Score:
0
Max. score:
4
Remarks on result:
other: Severity rating for both intact and abraded skin sites
Irritant / corrosive response data:
Average skin reaction for 24 and 72 hours after the start of treatment calculated for intact and abraded skin [no individual scores or any further information presented in paper]

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: other: evaluation criteria adopted from those in use by the National Institute for Occupational Safety and Health
Conclusions:
Platinum dioxide was not irritant in a limited (pre-GLP) study, involving 24-hr occluded application to the intact and abraded skin of 6 male rabbits.
Executive summary:

In a pre-GLP study, the dermal irritancy of 14 materials, including platinum dioxide, was assessed in albino rabbits. Test materials, mixed with water, were applied to intact and abraded skin of 6 male albino rabbits as 24-hour occluded patches. Coverings were then removed and sites scored immediately and 48 hours later, using a scale from 0 (non-irritant) to 4 (corrosive).

Platinum dioxide failed to give any indication of irritation (score 0) on both intact and abraded skin (mean of reactions at 24 and 72 hours). No classification for skin irritancy is required according to EU CLP criteria (EC 1272/2008), based on the results of this study.