Registration Dossier

Administrative data

Description of key information

In an acute oral toxicity study, an LD50 of greater than 3.4 g/kg bw was reported in male rats gavaged with platinum dioxide, and observed for up to 14 days (Holbrook et al., 1975).  
No relevant acute dermal or inhalation toxicity data were identified, or are required at this tonnage.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
3 400 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

No relevant human acute toxicity data were identified.

 

In an acute oral toxicity study, groups of male Sprague-Dawley rats were administered platinum dioxide by stomach tube and observed for 14 days. Using the prescribed statistical method, the acute oral median lethal dose (LD50) was found to exceed 3.4 g/kg bw. Based on the results of this study, platinum dioxide should not be classified for acute oral toxicity according to EU CLP criteria (EC 1272/2008).

 

No acute dermal or inhalation toxicity data were identified, or are required at this tonnage (1-10 tpa).


Justification for selection of acute toxicity – oral endpoint
Scientifically acceptable (non-guideline) study, and the only acute oral toxicity study available.

Justification for classification or non-classification

Based on the results of the available acute oral rat study, platinum dioxide does not require classification for acute oral toxicity according to EU CLP criteria (EC 1272/2008).

No clear evidence of specific target organ toxicity was noted. As such, classification for STOT-SE is not considered appropriate.