Registration Dossier

Administrative data

Endpoint:
sub-chronic toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: only secondary literature

Data source

Referenceopen allclose all

Reference Type:
other: ECHA disseminated dossier
Title:
ECHA disseminated dossier
Year:
2014
Bibliographic source:
ECHA disseminated dossier
Report Date:
2014
Reference Type:
secondary source
Title:
not applicable
Author:
not applicable
Year:
2008
Bibliographic source:
GESTIS-database on hazardous substances - Information system on hazardous substances of the German Social Accident Insurance

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Rats and guinea pigs were exposed to vapors and aerosols of trifluoroacetic acid for 4 hrs/day during 5 or 4 months.
GLP compliance:
not specified
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: rats and guinea pigs
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
other: inhalation of vapours and aerosols
Type of inhalation exposure:
not specified
Vehicle:
not specified
Remarks on MMAD:
MMAD / GSD: no data
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
4 hrs/day for 5 months (rats) or 4 months (guinea pigs)
Frequency of treatment:
6 times a week
Doses / concentrationsopen allclose all
Remarks:
Doses / Concentrations:
0.4-0.7 mg/L (guinea pigs)
Basis: no data
Remarks:
Doses / Concentrations:
0.025-0.05 mg/L (rats)
Basis: no data
No. of animals per sex per dose:
48 rats (12 served as control) or 30 guinea pigs (10 served as control).
Control animals:
yes

Results and discussion

Effect levels

open allclose all
Dose descriptor:
LOAEL
Effect level:
< 0.05 mg/L air
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: LOAEL (rat): severe signs of irritation on the respiratory pathway and the eyes, effects in the liver and kidney, and body weight loss.
Dose descriptor:
LOAEL
Effect level:
< 0.7 mg/L air
Based on:
test mat.
Sex:
not specified
Basis for effect level:
other: LOAEL (guinea pig): severe signs of irritation on the respiratory pathway and the eyes, effects in the liver and kidney, and body weight loss.

Target system / organ toxicity

Critical effects observed:
not specified

Applicant's summary and conclusion