Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

There are no data available concerning the skin sensitisation potential of trifluoroacetic acid (CAS 76-05-1). Since the substance is classified with H314, testing for skin sensitization is not required (Regultion 1907/2006, Annex VII, Column 2, Section 8.3).

In approximation, read across from the structurally similar compound, ethyl trifluoroacetate (CAS 383-63-1), was used. This substance is appropriate for read-across as the ethyl group was not known to induce sensitisation. In a LLNA (in vivo) the read-across substance ethyl trifluoroacetate did not induce delayed contact hypersensitivity in the murine Local Lymph Node Assay (stimulation index < 1).

Key value for chemical safety assessment

Skin sensitisation

Link to relevant study records
skin sensitisation: in vivo (LLNA)
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Study period:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: see 'Remarks'
The study as inserted into the disseminated ECHA dossier is a GLP and an OECD guideline study with a structurally similar compound, ethyl trifluoroacetate. This substance is appropriate for read-across as the ethyl group was not known to induce sensitisation.
< 1
Interpretation of results:
not sensitising
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed (not sensitising)

Respiratory sensitisation

Endpoint conclusion
Endpoint conclusion:
no study available

Justification for classification or non-classification

Classification, Labelling, and Packaging Regulation (EC) No 1272/2008

The available experimental test data are reliable and suitable for classification purposes under Regulation (EC) No 1272/2008. As a result the substance is not considered to be classified as skin sensitiser under Regulation (EC) No 1272/2008, as amended for the tenth time in Regulation (EU) No 2017/776.