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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation / corrosion, other
Remarks:
in vitro
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1998
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Scientifically sound publication which provides clear results

Data source

Reference
Reference Type:
publication
Title:
Evaluation of the Corrositex Method to Determine the Corrosivity Potential of Surfactants, Surfactant-Based Formulations, Chemicals, and Mixtures
Author:
Gordon VC et al.
Year:
1998
Bibliographic source:
Advances in Animal Alternatives for Safety and Efficacy Testing, chapter 32, edited by Salem H. & Katz S.A.

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 435 (In Vitro Membrane Barrier Test Method for Skin Corrosion)
Deviations:
no
Principles of method if other than guideline:
Corrositex TM is a quantitative in vitro corrosivity test. The model is based on the time required for the test substance to pass through a biobarrier membrane and produce a change in a chemical detection system.
GLP compliance:
not specified

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
other: not applicable
Strain:
other: not applicable
Details on test animals and environmental conditions:
Not relevant, as it is an in vitro test.

Test system

Type of coverage:
other: not applicable
Preparation of test site:
other: not applicable
Vehicle:
other: not applicable
Controls:
other: not applicable
Amount / concentration applied:
Not applicable
Duration of treatment / exposure:
Not applicable
Observation period:
Not applicable
Number of animals:
Not applicable

Results and discussion

In vivo

Results
Irritation parameter:
other: corrosivity
Basis:
other: mean of breakthrough time
Time point:
other: 0:04:30 (4 minutes and 30 seconds)
Reversibility:
other: not applicable
Remarks on result:
other: When results of "> 3 to 60 minutes" are obtained, the substance is consequently categorized to "Packing Group II"

Any other information on results incl. tables

The study was performed at the time that the Corrositex® method went out to the market. It was the aim of the study to demonstrate the utility, reproducibility, and relevance of the Corrositex® method in prediction of the potential dermal corrosion. Therefore 85 substances with known classification and labelling were tested/ screened in this method, showing whether the method can correctly assign the substances to their correct packing group. Trifluoroacetic acid (TFA) was one of the substances tested. Results of the Corrositex® test approved the corrosive characteristics of TFA.

Applicant's summary and conclusion

Interpretation of results:
other: Packing group II and Category 1A (corrosive)
Remarks:
Criteria used for interpretation of results: other: UN Dangerous Goods Transport Regulations and CLP/GHS classification and labelling