Registration Dossier

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Study period:
1967
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Some essential data are missing but in general a scientifically sound paper.

Data source

Reference
Reference Type:
publication
Title:
Toxic Actions of the Metabolites of Halothane: LD50 and Some Metabolic Effects of Trifluoroethanol and Trifluoroacetic Acid in Mice and Guinea Pigs
Author:
Airaksinen MM and Tammisto T
Year:
1968
Bibliographic source:
Ann. Med. Exp 46: 242 - 248
Report Date:
1967

Materials and methods

Test guideline
Qualifier:
no guideline required
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
mouse
Strain:
not specified
Sex:
male

Administration / exposure

Route of administration:
other: intraperitoneal and intravenously
Vehicle:
water
Doses:
4 - 6 doses, not detailed.
No. of animals per sex per dose:
5 - 40 mice per dose
Control animals:
other: yes, but used as a basis for comparison for other measurements/ parameters than mortality e.g ATP, lactic acid, pyravic acid and citric acid content in mice tissues.

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
test mat.
Remarks on result:
other: administered intraperitoneally
Sex:
male
Dose descriptor:
LD50
Effect level:
1 200 mg/kg bw
Based on:
test mat.
Remarks on result:
other: administered intravenously

Any other information on results incl. tables

The test substance had no effect on all other parameters tested in the study (levels of ATP, lactic acid, pyruvic acid in liver and muscle and citric acid in brain, muscle, heart and kidney).

Applicant's summary and conclusion