Registration Dossier

Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
2010
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was performed in compliance with the GLP. The purpose of this acute inhalation study was focussed on the determination of the irritant potential of TFA on the upper respiratory tract in rat rather than the determination of the LC50 value.

Data source

Reference
Reference Type:
other: ECHA disseminated dossier
Title:
No information
Report Date:
2014

Materials and methods

Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Administration / exposure

Duration of exposure:
h

Results and discussion

Effect levelsopen allclose all
Sex:
male
Dose descriptor:
other: NOAEC
Effect level:
ca. 300 mg/m³ air (nominal)
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: Irritation effects on the upper respiratory tract
Sex:
male
Dose descriptor:
other: NOAEC
Effect level:
>= 327.7 - <= 344.1 mg/m³ air (analytical)
Based on:
test mat.
Exp. duration:
4 h
Remarks on result:
other: Irritation effects on the upper respiratory tract

Applicant's summary and conclusion