Registration Dossier

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: A secondary literature only

Data source

Referenceopen allclose all

Reference Type:
other: ECHA disseminated dossier
Title:
ECHA disseminated dossier
Year:
2014
Bibliographic source:
ECHA disseminated dossier
Report Date:
2014
Reference Type:
secondary source
Title:
not applicable
Author:
not applicable
Year:
2008
Bibliographic source:
GESTIS-database on hazardous substances - Information system on hazardous substances of the German Social Accident Insurance

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
not specified
Remarks:
due to the minimum information given
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses:
Not indicated precisely. Only from the results one can assume that at least the following concentrations were used: 250 mg/kg bw and 1000 mg/kg bw
No. of animals per sex per dose:
90 rats in the study. Number of animals per sex per dose not indicated.
Control animals:
no

Results and discussion

Effect levelsopen allclose all
Sex:
not specified
Dose descriptor:
LD100
Effect level:
1 000 mg/kg bw
Based on:
test mat.
Sex:
not specified
Dose descriptor:
LD0
Effect level:
250 mg/kg bw
Based on:
test mat.
Sex:
not specified
Dose descriptor:
other: LD10
Effect level:
500 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

In the clinical picture, breathing disturbances similar to those that occur in acute inhalation poisoning are observed. In individual animals the motor activity is intensified immediately after administration of the substance, although the animals display less movement and motor activity more often. Varying degrees of haemorrhaging and necrosis in the mucous membranes of the stomach, dystrophic changes in the liver, kidneys and brain were detected in macro-and micro-investigations of organ of dead rats.

Applicant's summary and conclusion