Registration Dossier
Registration Dossier
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EC number: 425-320-1 | CAS number: 690-39-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP - Guideline study.
Data source
Reference
- Reference Type:
- other: inquiry result from ECHA
- Title:
- Unnamed
- Year:
- 2 013
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Guidelines No. 471 and 472, May 1983 Ames test
- GLP compliance:
- yes
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- -
- EC Number:
- 425-320-1
- EC Name:
- -
- Cas Number:
- 690-39-1
- Molecular formula:
- C3H2F6
- IUPAC Name:
- 1,1,1,3,3,3-hexafluoropropane
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella typhimurium/ TA100 TA1535 TA98 TA97 Escherichia coli/ WP2uvrA(pKM101)
- Metabolic activation system:
- With aroclor 1254 rat liver induced S9-mix
Results and discussion
Test results
- Species / strain:
- bacteria, other: Salmonella typhimurium/ TA100 TA1535 TA98 TA97 Escherichia coli/ WP2uvrA(pKM101)
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Additional information on results:
- Observations:
none
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative with metabolic activation
negative without metabolic activation
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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