[No public or meaningful name is available]

Basic toxicokinetics

Administrative data

Endpoint:

basic toxicokinetics

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

other: no test guideline stated, GLP compliance

Data source

Reference

Reference Type:

other: inquiry result from ECHA

Title:

Unnamed

Year:

2013

Materials and methods

Objective of study:

other: see field "Details on study design"

Test guideline

Qualifier:

according to guideline

Guideline:

other: No specific reference to the test guideline has been given.

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

425-320-1

EC Name:

-

Cas Number:

690-39-1

Molecular formula:

C3H2F6

IUPAC Name:

1,1,1,3,3,3-hexafluoropropane

Radiolabelling:

no

Test animals

Species:

other: rats

Administration / exposure

Route of administration:

inhalation

Vehicle:

other: None

Details on exposure:

Method of administration or exposure: Closed chamber recirculating gas uptake system

Duration and frequency of treatment / exposure:

Duration of exposure per day: 6 hours

No. of animals per sex per dose / concentration:

Male: 3 animals at 100 mg/kg
Male: 3 animals at 530 mg/kg
Male: 3 animals at 2350 mg/kg
Male: 3 animals at 7300 mg/kg
Male: 3 animals at 18000 mg/kg

Details on study design:

Objective of study: The aim of the studies was to measure tissue:air partition
coefficients and to describe the kinetics of the substance,
via recirculating gas uptake exposure methods, and to look
for and identify potential metabolities in blood and urine
after inhalation exposure to the substance.

Results and discussion

Any other information on results incl. tables

- The PBPK model could no adequately describe the disappearance of the substance from the chamber atmosphere during gas uptake experiments with the assumption that metabolism was the cause of chemical disappearance. The pattern of loss was, in fact, inconsistent with either first-order or saturable metabolism.

- Possible cause of the unexplained loss may be associated with carbon dioxide exhalation during the exposure although final confirmation would require further investigation.

- The substance had low solubility (partition) in blood and tissues and had minimal, if any, enzymatic metabolism in rats

- Explicit analyses for potential metabolities in blood, urine, and feces failed to detect anything but the substance

itself.