Registration Dossier
Registration Dossier
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EC number: 944-459-3 | CAS number: -
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
3h EC50 (activated sludge, domestic) = 135 mg/L (respiration inhibition test, similar to OECD 209)
Key value for chemical safety assessment
- EC50 for microorganisms:
- 135 mg/L
Additional information
The read-across to the structurally related category member was conducted in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5. The key, non-GLP test with C12AS Na (CAS 151-21-3) was performed according to a guideline similar to OECD 209. The EC50 values of 188 and 135 mg/L (nominal concentrations) were obtained for the endpoint respiration inhibition after 30 minutes and 3 hours of exposure, respectively. The 3-hour EC50 value of 135 mg/L, being the most sensitive value, was used for the PNEC STP derivation of C12-14AS MIPA (CAS 85681-66-9).
One study is available for C12-14AS MEA (CAS 90583-16-7). A GLP test according to DIN 38412 part 8 with Pseudomonas putida using was conducted by BASF (1991a). In this study, the growth inhibition of Pseudomonas putida was recorded after approximately 16 hours of exposure. The 16-h EC10 value was determined to be 1769 mg a.i./L (nominal concentration).
Finally, a P. putida test is available for C12-14AS TEA (CAS 90583-18-9; BASF 1992). In this study, the growth inhibition of Pseudomonas putida was recorded after approximately 16 hours of exposure. The 16-h EC10 value was determined to be 1084 mg a.i./L (nominal concentration).
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