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Diss Factsheets
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EC number: 813-782-0 | CAS number: 5912-87-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- 1999
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- significant methodological deficiencies
- Remarks:
- The study was disregarded since positive reactions observed could have been caused by cross reactions with Isoeugenol.
Data source
Reference
- Reference Type:
- publication
- Title:
- Isoeugenol is an important contact allergen: can it be safely replaced with isoeugenyl acetate?
- Author:
- White IR1, Johansen JD, Arnau EG, Lepoittevin JP, Rastogi S, Bruze M, Andersen KE, Frosch PJ, Goossens A and Menné T.
- Year:
- 1 999
- Bibliographic source:
- Contact Dermatitis. 41(5):272-275.
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- study with volunteers
- Principles of method if other than guideline:
- 155 consecutive subjects were patch tested to isoeugenyl acetate and skin reactions were evaluated.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2-methoxy-4-prop-1-enylphenyl acetate
- EC Number:
- 202-236-1
- EC Name:
- 2-methoxy-4-prop-1-enylphenyl acetate
- Cas Number:
- 93-29-8
- IUPAC Name:
- 2-methoxy-4-prop-1-en-1-ylphenyl acetate
- Test material form:
- not specified
Constituent 1
Method
- Type of population:
- general
- Ethical approval:
- not specified
- Subjects:
- - Number of subjects exposed: 155
- Clinical history:
- None
- Controls:
- None
- Route of administration:
- dermal
- Details on study design:
- TYPE OF TEST(S) USED: patch test (epicutaneous test)
ADMINISTRATION
- Type of application: occlusive
- Description of patch: Test item was applied under Finn Chambers (using filter paper discs for the ethanol dilutions)
- Vehicle / solvent: Ethanol
- Concentrations: 0.13, 0.4 and 1.2% in ethanol
- Testing/scoring schedule: Skin reactions were scored on Day 2 and 4 after 2 days occlusion.
EXAMINATIONS
- Grading/Scoring system: Standard international method of recording was used.
Results and discussion
- Results of examinations:
- NO. OF PERSONS WITH REACTIONS
- 12 individuals showed a reaction. 6 (3.9%) had an allergic reaction to 1.2% isoeugenyl acetate at Day 4. The reactions to the other 2 dilutions tended to be graded. However the positive reactions observed could have been caused by cross reactions with Isoeugenol.
Any other information on results incl. tables
None
Applicant's summary and conclusion
- Conclusions:
- The study was disregarded since positive reactions observed could have been caused by cross reactions with Isoeugenol.
- Executive summary:
In a patch test, 155 consecutive subjects were patch tested to isoeugenyl acetate (0.13, 0.4 and 1.2% in ethanol) under occlusive patch. Two days after application, skin reactions were scored on Day 2 and 4.
12 individuals showed a reaction. 6 (3.9%) had an allergic reaction to 1.2% isoeugenyl acetate at Day 4. The reactions to the other 2 dilutions tended to be graded. However the positive reactions observed could have been caused by cross reactions with Isoeugenol.
The study was disregarded since positive reactions observed could have been caused by cross reactions with Isoeugenol.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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