Registration Dossier
Registration Dossier
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EC number: 206-386-9 | CAS number: 335-27-3
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 970
- Report date:
- 1970
Materials and methods
- Principles of method if other than guideline:
- Subjects exposed continuousy for six hours, and observed at intervals during that time. Observed daily over the subsequent 14 day observation period.
- GLP compliance:
- no
- Test type:
- fixed concentration procedure
Test material
- Reference substance name:
- 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)cyclohexane
- EC Number:
- 206-386-9
- EC Name:
- 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)cyclohexane
- Cas Number:
- 335-27-3
- Molecular formula:
- C8F16
- IUPAC Name:
- 1,1,2,2,3,3,4,5,5,6-decafluoro-4,6-bis(trifluoromethyl)cyclohexane
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: albinos of the CFY strain
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Not specified
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- ca. 360 min
- Concentrations:
- 40 000 ppm v/v (i.e., 4%, the estimated vapour pressure concentration)
- No. of animals per sex per dose:
- 5 male, 5 female
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 40 000 ppm
- Based on:
- test mat.
- Exp. duration:
- 360 min
- Mortality:
- None
- Clinical signs:
- other: None
- Body weight:
- Transient weight loss in males, but by the end of the test was comparable with control.
- Gross pathology:
- None
- Other findings:
- None noted
Any other information on results incl. tables
"It is concluded that the samples of tested Perfluoro-1,3 -dimethylcyclohexane have no appreciable acute inhalation toxicity to the rat."
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- No inhalation toxicity at 4% v/v for this material.
- Executive summary:
No inhalation toxicity at 4% v/v for this material.
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