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Ecotoxicological information

Short-term toxicity to fish

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Reference
Endpoint:
short-term toxicity to fish
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Data is from computational model developed by USEPA
Justification for type of information:
Data is from computational model developed by USEPA
Qualifier:
according to
Guideline:
other: Modeling database
Principles of method if other than guideline:
ECOSAR estimates log Kow values using the US EPA's KOWWIN Program for aquatic toxicity.Toxicity of a chemical was measured on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program based upon the octanol /water partition coefficient (Kow). Data from ECOSAR class,neutral organics was used.

The estimation methods in EPI Suite™ have been developed by government, academic, and private sector researchers over many years and represent some of the best techniques currently available. The intended application domain of EPI Suite is organic chemicals, and inorganic as well as organometallic chemicals generally can be considered outside the domain.
GLP compliance:
no
Analytical monitoring:
not specified
Test organisms (species):
other: Fish
Test type:
not specified
Water media type:
not specified
Total exposure duration:
96 h
Reference substance (positive control):
not specified
Duration:
96 h
Dose descriptor:
EC50
Effect conc.:
1 101 mg/L
Nominal / measured:
estimated
Conc. based on:
test mat.
Basis for effect:
mortality
Remarks on result:
other: Neutral organics
Conclusions:
On the basis of EPI suite, ECOSAR version 1.1, the LC 50 value for short term toxicity to fish was predicted to be 1101 mg/l for test material in 96hrs.
Based on this value it can be concluded that the substance is considered to be toxic to aquatic environment and can not be classified as per the criteria mentioned in CLP regulation.
Executive summary:

Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted.On the basis of this program, the LC 50 value for short term toxicity to fish was predicted to be 1101 mg/l for test materialin 96 hrs.Based on this value it can be concluded that the substance is considered to be not toxic to aquatic environment and can not be classified in as per the criteria mentioned in CLP regulation.

Description of key information

Short term toxicity to fish:

Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted.On the basis of this program, the LC 50 value for short term toxicity to fish was predicted to be 1101 mg/l for test materialin 96 hrs.Based on this value it can be concluded that the substance is considered to be not toxic to aquatic environment and can not be classified in as per the criteria mentioned in CLP regulation.

Key value for chemical safety assessment

Additional information

Short term toxicity to fish:

Short term toxicity to fish for test material was evalauted , prediction and data from peer reviewed journal was used to concluded the toxicity potential of test material on fish as summarized below.

Based on the prediction done by EPI suite, ECOSAR version 1.1, on the basis of similarity of structure to chemicals for which the aquatic toxicity has been previously measured by structure-activity relationships (SARs) program, the LC 50 value for short term toxicity to fish was predicted.On the basis of this program, the LC 50 value for short term toxicity to fish was predicted to be 1101 mg/l for test materialin 96 hrs.Based on this value it can be concluded that the substance is considered to be not toxic to aquatic environment and can not be classified in as per the criteria mentioned in CLP regulation.

The above prediction was further supported by data from reviewed handbooks and peer reviewed journals, In acute fish toxicity study on species Carassius auratus (Goldfish) time to 50% mortality of organisms (LC50) of test substance was reported to be 480 mg/l on the basis of mortality effect with exposure period 3.02 hrs.Mentioned concentration indicate that the test substance was non toxic to fish.

In another study , short term fish toxicity of test chemical on test species Oryzias latipes (Japanese Medaka) the lethal concentration (LC50) for exposure period of 48 hrs. in static freshwater system and test temperature 30 deg.C was observed to be 1000 mg/l. Thus based on the lethal concentration it is concluded that the test substance was non hazardous to aquatic environment.

In another study the effect of test material on the mortality of Danio rerio. The study was conducted in accordance with OECD Guideline 203 (Fish, Acute Toxicity Test) in a static sysytem. Preparation of the test solutions/dispersions :The test solution was prepared by dissolving 1 g of the test substance in 10 liters deionized water with continuous stirring.Observations (mortality, visible symptoms, pH, Temperature, dissolved oxygen content) were recorded after 24 hours, 48 hours, 72 hours and 96 hours of the start of the experiment.Based on nominal concentration, the median lethal concentration LC-50 (96 h) for test substance on Danio rerio was found to be >100 mg/L according to probit analysis. The fishes were found to be freely swimming in the bowl aquaria without showing any abnormal symptoms. No mortalities were observed at the test concentration of 100 mg/l. It can be concluded from the value that the test substance is not toxic to the aquatic environment can be considered to be “not classified” as per the CLP classification criteria.