2-ethoxybenzoic acid

Hydrolysis

Link to relevant study record(s)

Reference

Endpoint:

hydrolysis

Type of information:

read-across from supporting substance (structural analogue or surrogate)

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Remarks:

experimental data of read across substances

Justification for type of information:

Data for the target chemical is summarized based on the structurally similar read across chemicals

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Reason / purpose for cross-reference:

read-across source

Qualifier:

according to guideline

Guideline:

other: as mentioned below

Principles of method if other than guideline:

WoE report is based on two hydrolysis studies as-
1., 2. and 3.

GLP compliance:

not specified

Radiolabelling:

not specified

Analytical monitoring:

not specified

Estimation method (if used):

1. No data available
2. Structure estimation method
3. No data available

Temp.:

17 °C

Remarks:

1. The study was performed at pH 3.5, 5.0, 7.4, 9.5 and 11.3, respectively.

Remarks:

2. Details not known

Remarks:

3. The study was performed at pH 5, 7 and 9, respectively.

Positive controls:

not specified

Negative controls:

not specified

Transformation products:

not specified

pH:

3.5

Temp.:

17 °C

DT50:

12.5 d

Remarks on result:

other: 1. Hydrolysis rate constant of test chemical was determined to be 0.00000065/sec

pH:

5

Temp.:

17 °C

DT50:

5.4 d

Remarks on result:

other: 1. Hydrolysis rate constant of test chemical was determined to be 0.0000015/sec

pH:

7.4

Temp.:

17 °C

DT50:

6.3 d

Remarks on result:

other: 1. Hydrolysis rate constant of test chemical was determined to be 0.0000013/sec

pH:

9.5

Temp.:

17 °C

DT50:

2.2 d

Remarks on result:

other: 1. Hydrolysis rate constant of test chemical was determined to be 0.0000037/sec

pH:

11.3

Temp.:

17 °C

DT50:

1.2 h

Remarks on result:

other: 1. Hydrolysis rate constant of test chemical was determined to be 0.00064/sec

pH:

7

DT50:

1.4 yr

Type:

second order

Remarks on result:

other: 2. Hydrolysis rate constant is 0.16 L/mol-sec.

pH:

8

DT50:

51 d

Type:

second order

Remarks on result:

other: 2. Hydrolysis rate constant is 0.16 L/mol-sec.

DT50:

> 30 d

Remarks on result:

other: 3. The study was performed at pH 5, 7 and 9, respectively.

Validity criteria fulfilled:

not specified

Conclusions:

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 6.3 days to 1.4 yrs, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.

Executive summary:

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

The hydrolysis half-life of the test chemical was determined. The study was performed at pH 3.5, 5.0, 7.4, 9.5 and 11.3 & at a temperature of 17⁰C, respectively. The half-life value of test chemical was determined to be 12.5 days, 5.4 days, 6.3 days, 2.2 days and 1.2 hrs with a corresponding hydrolysis rate constant of 0.00000065/sec, 0. 0000015/sec, 0. 0000013/sec, 0. 0000037/sec & 0. 00064/sec at pH 3.5, 5.0, 7.4, 9.5 and 11.3 & at a temperature of 17⁰C, respectively. Based on the half-life value (i.e, 6.3 days at pH 7.4), it is concluded that the test chemical is slowly hydrolysable in water.

In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

For the test chemical, the hydrolysis half-life was determined. The study was performed at pH 5, 7 and 9, respectively. The half-life value of test chemical was determined to be > 30 days at pH 5, 7 and 9, respectively. Based on this half-life value, it is concluded that the test chemical is not hydrolysable.

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 6.3 days to 1.4 yrs, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.

Description of key information

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 6.3 days to 1.4 yrs, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.

Additional information

Data available for the test chemical has been reviewed to determine the half-life of hydrolysis as a function of pH. The studies are as mentioned below:

 

The hydrolysis half-life of the test chemical was determined. The study was performed at pH 3.5, 5.0, 7.4, 9.5 and 11.3 & at a temperature of 17⁰C, respectively. The half-life value of test chemical was determined to be 12.5 days, 5.4 days, 6.3 days, 2.2 days and 1.2 hrs with a corresponding hydrolysis rate constant of 0.00000065/sec, 0. 0000015/sec, 0. 0000013/sec, 0. 0000037/sec & 0. 00064/sec at pH 3.5, 5.0, 7.4, 9.5 and 11.3 & at a temperature of 17⁰C, respectively. Based on the half-life value (i.e, 6.3 days at pH 7.4), it is concluded that the test chemical is slowly hydrolysable in water.

 

In an another study, the half-life and base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.16L/mol-sec with a corresponding half-lives of 1.4 yrs and 51 days at pH 7 and 8, respectively. Based on the half-life values, it is concluded that the test chemical is not hydrolysable.

 

For the test chemical, the hydrolysis half-life was determined. The study was performed at pH 5, 7 and 9, respectively. The half-life value of test chemical was determined to be > 30 days at pH 5, 7 and 9, respectively. Based on this half-life value, it is concluded that the test chemical is not hydrolysable.

 

On the basis of the experimental studies of the test chemical and applying the weight of evidence approach, the hydrolysis half-life value of the test chemical can be expected to be ranges from 6.3 days to 1.4 yrs, respectively. Thus, based on this half-life value, it can be concluded that the test chemical undergoes slow to negligible hydrolysis in water.