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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Justification for type of information:
Data is from peer-reviewed journal

Data source

Reference
Reference Type:
publication
Title:
Fragrance raw materials monographs: Menthone Racemic
Author:
D. L. J. OPDYKE
Year:
1976
Bibliographic source:
Food and Cosm. Toxicology Vol 14, 1976, Pp 475-476,1976

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: as below
Principles of method if other than guideline:
Acute oral toxicity study of 2-isopropyl-5-methylcyclohexanone in rats
GLP compliance:
not specified
Test type:
other: No data
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
liquid
Details on test material:
- Name of test material: 2-isopropyl-5-methylcyclohexanone
- Molecular formula: C10H18O
- Molecular weight: 154.2512g/mol
- Smiles notation: C1([C@@H](CC[C@@H](C1)C)C(C)C)=O
- InChl: 1S/C10H18O/c1-7(2)9-5-4-8(3)6-10(9)11/h7-9H,4-6H2,1-3H3
- Substance type: Organic
- Physical state: liquid
Specific details on test material used for the study:
- Name of test material (as cited in study report): 2-isopropyl-5-methylcyclohexanone
- Molecular formula (if other than submission substance): C10H18O
- Molecular weight (if other than submission substance): 154.2512 g/mole
- Substance type: Organic
- Physical state: Liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No data available

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available
Doses:
2432.88 mg/kg bw
No. of animals per sex per dose:
No data available
Control animals:
not specified
Details on study design:
No data available
Statistics:
No data available

Results and discussion

Preliminary study:
No data available
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
ca. 2 432.88 mg/kg bw
Based on:
test mat.
95% CL:
2 031.12 - 2 923.92
Remarks on result:
other: 50% mortality observed
Mortality:
50% mortality observed in treated rats at 2432.88 mg/kg bw
Clinical signs:
No data available
Body weight:
No data available
Gross pathology:
No data available
Other findings:
No data available

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
LD50 was considered to be 2432.88 mg/kg bw (2031.12 - 2923.92) when rats were treated with 2-isopropyl-5-methylcyclohexanone orally.
Executive summary:

In a acute oral toxicity study, rats were treated with 2-isopropyl-5-methylcyclohexanone in the concentration of 2432.88 mg/kg bw orally. 50% mortality observed in treated rats at 2432.88 mg/kg bw. Therefore, LD50 was considered to be 2432.88 mg/kg bw (2031.12 - 2923.92) when rats were treated with 2-isopropyl-5-methylcyclohexanone orally.