Registration Dossier
Registration Dossier
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EC number: 203-583-1 | CAS number: 108-44-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (comparable to standards)
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 988
- Reference Type:
- review article or handbook
- Title:
- IUCLID Dataset 4-Isopropylaniline
- Author:
- ECB
- Year:
- 2 000
- Bibliographic source:
- European Chemical Bureau(ECB) European Commission
- Report date:
- 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not applicable
- GLP compliance:
- yes
Test material
- Reference substance name:
- 4-isopropylaniline
- EC Number:
- 202-797-2
- EC Name:
- 4-isopropylaniline
- Cas Number:
- 99-88-7
- Molecular formula:
- C9H13N
- IUPAC Name:
- 4-isopropylaniline
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Results and discussion
Effect levelsopen allclose all
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 030 mg/kg bw
- Remarks on result:
- other: rat
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 000 mg/kg bw
- Remarks on result:
- other: rat
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- Mean value LD50 = 1015 mg/kg bw (used for classification)
Risk of cutaneous absorption. Risk of methaemoglobin formation even after skin contact (leads to increased classification).
Symptoms may be delayed. - Executive summary:
As mention in chapter toxicikinetics read across to p-isopropyl aniline is appropriate and justified by ECB 2000 (peer reviewed data collection). p-Isopropyl aniline was applied to the skin of male and female rats as described by OECD TG 402 under GLP conditions to determine acute dermal toxicity.
The LD50 for males is 1000 mg/kg bw and for females 1030 mg/kg bw (Hoechst AG 1988)
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