Registration Dossier
Registration Dossier
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EC number: 203-583-1 | CAS number: 108-44-1
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Adequacy of study:
- other information
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Haemoglobin adducts from aromatic amines and tobacco-specific nitrosamines in pregnant smoking and non-smoking women
- Author:
- Branner B, Kutzer C, Zwickenpflug W, Scherer G, Heller WD, Richter E
- Year:
- 1 998
- Bibliographic source:
- Biomarkers 3, 35-47
- Reference Type:
- publication
- Title:
- Hemoglobin adducts of anomatic amines: association with smoking status and type of tobacco
- Author:
- Bryant MS, Vineis P, Skipper PL, Tannenbaum StR
- Year:
- 1 988
- Bibliographic source:
- Proc Natl Acad Sci (USA) 85, 9788-9791
- Reference Type:
- publication
- Title:
- Determination of human exposure to carcinogenic aromatic amines from hemoglobin adducts in selected population groups
- Author:
- Skipper PL, Bryant MS, Tannenbaum StR
- Year:
- 1 988
- Bibliographic source:
- Proc Int Conf Carcinog Mutagen Responses p 65-71
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- not applicable
- Principles of method if other than guideline:
- Blood samples were collected from voluteers (active smoking and non-smoking) to determine hemoglobin adducts with aromatic amines(e.g. m-toluidine).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- m-toluidine
- EC Number:
- 203-583-1
- EC Name:
- m-toluidine
- Cas Number:
- 108-44-1
- Molecular formula:
- C7H9N
- IUPAC Name:
- 3-methylaniline
- Details on test material:
- constituent of tabacco smoke :no further data
Constituent 1
Method
- Subjects:
- volunteers (male and females)
- Route of exposure:
- inhalation
- Reason of exposure:
- other: intentional, non-occupational
Results and discussion
- Clinical signs:
- no data
- Results of examinations:
- There was no significant difference in the adduct level between active smoking and non-smoking volunteers.
Adduct levels revaled to be higher using black tabacco than blond tabacco.
Any other information on results incl. tables
There was no significant difference in the adduct level between active smoking and non-smoking volunteers.
Adduct levels revaled to be higher using black tabacco than blond tabacco.
Applicant's summary and conclusion
- Conclusions:
- There was no significant difference in the adduct level between active smoking and non-smoking volunteers.
Adduct levels revaled to be higher using black tabacco than blond tabacco.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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