Registration Dossier
Registration Dossier
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EC number: 202-068-9 | CAS number: 91-44-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer-reivewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Acute oral toxicity in rats
- Author:
- Gloxhuber et al.
- Year:
- 1 978
- Bibliographic source:
- CLINICAL TOXICOLOGY
- Reference Type:
- other: authoritative database
- Title:
- Acute oral toxicity by using test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
- Reference Type:
- review article or handbook
- Title:
- Acute oral toxicity of test chemical
- Author:
- Richard J. Lewis
- Year:
- 2 012
- Bibliographic source:
- Sax's Dangerous Properties of Industrial Materials
- Reference Type:
- review article or handbook
- Title:
- Acute orl toxicity of test chemical.
- Author:
- McGraw Hill
- Year:
- 1 999
- Bibliographic source:
- McGraw Hill,1999
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity study of the given test chemical in rats.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 7-(diethylamino)-4-methyl-2-benzopyrone
- EC Number:
- 202-068-9
- EC Name:
- 7-(diethylamino)-4-methyl-2-benzopyrone
- Cas Number:
- 91-44-1
- Molecular formula:
- C14H17NO2
- IUPAC Name:
- 7-(diethylamino)-4-methyl-2H-chromen-2-one
- Details on test material:
- CAS no.: 91-44-1
EC / List no.: 202-068-9
Name: 7-(diethylamino)-4-methyl-2-benzopyrone
InChI:1S/C14H17NO2/c1-4-15(5-2)11-6-7-12-10(3)8-14(16)17-13(12)9-11/h6-9H,4-5H2,1-3H3
Smiles:c12c(ccc(c1)N(CC)CC)c(cc(=O)o2)C
Molecular formula:C14H17NO2
Molecular weight :231.2933 g/mole
Substance type:Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 4-Methyl-7-diethylaminocoumarin
- Molecular formula (if other than submission substance): C14H17NO2
- Molecular weight (if other than submission substance): 231.2933 g/mole
- Substance type: Organic
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- 50% mortality was observed in treated rats at 5000 mg/kg bw.
- Clinical signs:
- other: not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The acute oral LD50 value was considered to be 5000 mg/kg bw, when rats were treated with the given test chemical orally.
- Executive summary:
In a acute oral toxicity study, rats were treated with the given test chemical at the concentration of 5000 mg/kg bw orally. Animals were observed for mortality. 50% mortality was observed in treated rats at 5000 mg/kg bw. Therefore, The acute oral LD50 value was considered to be 5000 mg/kg bw, when rats were treated with the given test chemical orally.
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