Registration Dossier
Registration Dossier
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EC number: 277-554-7 | CAS number: 73612-40-5
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
Description of key information
Not readily biodegradable
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
For this substance there are no data on ready biodegradation as required in the Annex VII, but A.15,A.16,A.22 BOD5/COD tests and A.37 Zahn–Wellens (OECD 302B) and A.12 biooelimination test are available on the substance A, C, D and E, and used in a Weight of Evidence approach.
Klimish 1 BOD5/COD studies (performed in GLP) are available.
The data Biochemical Oxygen Demand (BOD5) and Chemical Oxygen Demand (COD) are the most commonly used parameters for the characterization of the biodegradability capacity. COD results are typically higher than BOD5 values, and the ratio vary depending on the characteristics of the substrate. This ratio has been commonly used as an indicator for biodegradation capacity, the "Biodegradability index" (B.I.).
As indicated in ECHA Guidance requirement R.7B, the BOD5 test is a traditional biodegradation test that is now replaced by the ready biodegradability tests. Therefore, this test should not be performed today for assessment of the ready biodegradability of substances. Older test data may, however, be used when no other degradability data are available. If the ratio BOD5/COD is => 0.5, the substance is regarded as being readily biodegradable.
The ratio BOD5/COD of the found BOD5 and COD values is less than 0.5 (if => 0.5, the substance is regarded as being readily biodegradable), therefore the substance showed no ready biodegradability.
Furthermore, a Klimish 2 bioelimination studies (A.37 Zahn–Wellens and A.12 method) showed an elimination of 89% after 21 days, as DOC removal. Another bioelimination study (method A.12) showed a 15% of elimination, therefore these test are related more on bioelimination capacity and no on the ready biodegradability capacity.
As a conclusion, the registered substance is considered no readily biodegradable.
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