Registration Dossier

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2011-09-13 to 2011-10-10
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Qualifier:
according to guideline
Guideline:
other: Guidelines for the Testing of chemicals 117 Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method (STATE ENVIRONMENT PROTECTION ADMINISTRATI0N OF CHINA 2004)
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
3.3
Temp.:
25 °C
Remarks on result:
other: no pH measurements
Remarks:
Mobile phase is neutral

Substance tR [min] k log k log Pow
Phenylacetonitrile  1.535 0.246 -0.609 0.84
Phenylacetonitrile 1.847 0.499 -0.302 1.56
Cinnamyl alcohol  1.689 0.371 -0.431 1.95
Nethyl benzoate  2.207 0.791 -0.102 2.2
Ethyl benzoate  2.624 1.13 0.053 2.64
Bromobenzene 3.079 1.499 0.176 2.99
Naphthalene 3.338 1.709 0.233 3.35
1,4-Dichlorobenzent  3.667 1.976 0.296 3.45
Biphenyl 4.063 2.298 0.361 3.98
Diphenyl ether  3.927 2.188 0.34 4.21
Test substance 3.168 1.571 0.196 3.3
Test substance 3.171 1.574 0.197 3.3
Conclusions:
The partition coefficient log Pow of the test substance was determined to be log Pow = 3.3 at 25 °C.
Executive summary:

A Reverse phase HPLC study was performed according to Guidelines for the Testing of chemicals 117 Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method (STATE ENVIRONMENT PROTECTION ADMINISTRATI0N OF CHINA 2004) to determine the partition coefficient of the test substance. The octanol/water partition coefficient of a test substance was computed by experimentally determining its capacity factor k and then calculation of the logPow. The partition coefficient log Pow of the test substance was determined to be log Pow = 3.3 at 25 °C.

Description of key information

The partition coefficient log Pow of the test substance was determined to be log Pow = 3.3 at 25 °C.

Key value for chemical safety assessment

Log Kow (Log Pow):
3.3
at the temperature of:
25 °C

Additional information

A Reverse phase HPLC study was performed according to Guidelines for the Testing of chemicals 117 Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) Method (STATE ENVIRONMENT PROTECTION ADMINISTRATI0N OF CHINA 2004) to determine the partition coefficient of the test substance. The octanol/water partition coefficient of a test substance was computed by experimentally determining its capacity factor k and then calculation of the logPow. The partition coefficient log Pow of the test substance was determined to be log Pow = 3.3 at 25 °C.