Registration Dossier
Registration Dossier
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EC number: 202-058-4 | CAS number: 91-30-5
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: data is from Authoritive data base
Data source
Reference
- Reference Type:
- other: authorative data base
- Title:
- Skin sensitization CAS No: 121573 (Sulfanilic acid)
- Author:
- IFA (GESTIS)
- Year:
- 2 016
- Bibliographic source:
- GESTIS Substance Database (Information System in Hazardous Substance of the Berufsgenossenscheftn)
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The skin sanitization test of Benzyl cyanide was conducted in guinea pigs to determine sensitization potential of Sulfanilic acid
- GLP compliance:
- not specified
- Type of study:
- guinea pig maximisation test
- Justification for non-LLNA method:
- not specified
Test material
- Reference substance name:
- Sulfanilic acid
- IUPAC Name:
- Sulfanilic acid
- Reference substance name:
- 121573
- IUPAC Name:
- 121573
- Reference substance name:
- 2044825
- IUPAC Name:
- 2044825
- Test material form:
- other: solid
- Details on test material:
- - Name of test material (as cited in study report): 4Aminobenzenesulfonic acid
- Molecular formula: C6H7NO3S
- Molecular weight: 173.19 g/mol
- Substance type: Organic
- Physical state: solid
-Smiles:S(c1ccc(N)cc1)(O)(=O)=O
-InChI:1S/C6H7NO3S/c7-5-1-3-6(4-2-5)11(8,9)10/h1-4H,7H2,(H,8,9,10)
Constituent 1
Constituent 2
Constituent 3
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- No data available
Study design: in vivo (non-LLNA)
Inductionopen allclose all
- Route:
- other: No data available
- Vehicle:
- no data
- Concentration / amount:
- No data available
Challengeopen allclose all
- Route:
- other: No data available
- Vehicle:
- no data
- Concentration / amount:
- No data available
- No. of animals per dose:
- No data available
- Details on study design:
- No data available
- Challenge controls:
- No data available
- Positive control substance(s):
- not specified
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- 1st reading
- Group:
- test chemical
- Dose level:
- No data available
- Clinical observations:
- Potential skin sensitizer
- Remarks on result:
- other: Reading: 1st reading. Group: test group. Dose level: No data available. Clinical observations: Potential skin sensitizer.
Any other information on results incl. tables
not specified
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The test material Sulfanilic acid (CAS No: 121573) was observed to be sensitizing on guinea pigs.
- Executive summary:
The skin sensitization reaction was carried out in guinea pigs by guinea pig maximization test for test chemical Sulfanilic acid (CAS No: 121573).
Since skin effects were observed the test chemical Sulfanilic acid (CAS No: 121573) was considered to be sensitizing to guinea pigs.
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