Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
genetic toxicity in vitro
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
other: Not applicable since exclusively summarizing data coming from an existing risk assessment (BUA Report) are presented as executive summary.

Data source

Reference
Reference Type:
other: Risk assessment
Title:
Phenylenediamines, BUA Report 97
Author:
GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance (BUA)
Year:
1992
Bibliographic source:
edited by the GDCh-Advisory Committee on Existing Chemicals of Environmental Relevance, S. Hirzel, Wissenschaftliche Verlagsgesellschaft, Birkenwaldstraße 44, 70191 Stuttgart, 1995

Materials and methods

Results and discussion

Applicant's summary and conclusion

Executive summary:

p-phenylenediamine causes gene mutation in bacteria following metabolic activation while results are negative without activation. Predominantly no effect on gene mutation were observed in fungi, even with metabolic activation, while positive results were recorded in mammalian cells. The damaging effects of p-phenylenediamine on DNA and chromosomes vary according to the test system, and both positive and negative findings have been obtained. p-phenylenediamine has been observed to form strongly mutagenic oxidation products which influence test results.