Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Direct observations: clinical cases, poisoning incidents and other

Administrative data

direct observations: clinical cases, poisoning incidents and other
Type of information:
other: observations after poisoning
Adequacy of study:
supporting study
other: Not applicable since exclusively summarizing data coming from an existing risk assessment (BUA Report) are presented as executive summary.

Data source

Materials and methods

Results and discussion

Applicant's summary and conclusion

Executive summary:

Acute oral intoxication with p-phenylenediamine manifests itself in man as local irritation, depletion of erythrocytes and skeletal muscle cells with acute renal failure, or as oedema of the head and neck with dyspnoea. Asthma attacks were also described at the turn of the century. p-Phenylenediamine is an allergen in man because of allergy to the para-group. Cases of photosensitization induced by p-phenylenediamine have also been recorded.