Registration Dossier
Registration Dossier
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EC number: 214-230-6 | CAS number: 1115-70-4
Endpoint summary
Administrative data
Description of key information
Additional information
In Annex X of the Regulation (EC) No 1907/2006 REACH concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), it is suggested, that "in the absence of toxicity data for soil organisms, the equilibrium partitioning method may be applied to assess the hazard to soil organisms.The choice of the appropriate tests depends on the outcome of the chemical safety assessment. In particular for substances that have a high potential to adsorb to soil or that are very persistent, the registrant shall consider long-term toxicity testing instead of short-term. These studies do not need to be conducted if direct and indirect exposure of the soil compartment is unlikely."
Considering its solubility, volatility and resultant Henry’s Law Constant, metformin hydrochlorid is expected, under equilibrium conditions, to exist principally in water.The substance has no industrial release to the compartment soil, has low potential for adsorption (based upon the log Koc), is not bioaccumulative and suggesting little hazardous potential towards soil organisms.Furthermore, results of aquatic tests suggesting little hazardous potential towards soil organisms. Therefore, the equilibrium partitioning method has been used to assess the hazard potential of metformin hydrochlorid for soil organisms.
Exposure assessment shows a RCR < 1 for soil compartment.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
