Registration Dossier
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EC number: 249-276-6 | CAS number: 28872-01-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Only a limit number of short-term toxicity to aquatic invertebrates studies are available for the substances under consideration. Therefore the test results of a number of alkyl-1,3-diaminopropanes and for dodecyltriamine Y were added to the dossier. Tri- and tetramines contain respectively about 22 – 11% diamines and for this reason the data for the diamines was added to the overview. It is considered reasonable to add dodecyltriamine Y as a worst-case as this substance is considered a the most toxic triamine. The study with dodecyltriamine Y is selected as the Key study as this study is a Klimisch 1. The LC50 of this study is therefore used as the Key value for chemical safety assessment as a reasonable worst-case. In the final risk assessment this value will not be critical as two chronic end points are available.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.077 mg/L
Additional information
Most of the short-term toxicity daphnia tests were conducted in a period when no reliable specific method of analyses was available. The concentrations were therefore not analytically verified, the reliability of the results is limited because of the poor solubility of the test substances and partial sorption onto the walls of test vessels. Hence, most of the tests were considered to be valid with restrictions. Only one acute daphnia test study is available with a Klimisch 1 which is for N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine (2372-82-9; dodecyltriamine Y). This substanceis used as a biocide and this substance is considered as the most ecotoxic substance for the alkyl triamines (3N).The observed LC50 for this substance of 0.0775 mg/L, suggests that the alkyl-1,3-diaminopropanes (2N) are more ecotoxic than the alkyl polyamines (>2N). Tri- and tetramines contain respectively about 22 – 11% diamines and for this reason the data for the diamines was added to the list of tests. For oleyl tetramine (4N) an EC50 (48 h) has been observed of 0.032 mg/L. This value is slightly lower than the value observed for dodecyltriamine Y. For oleyl triamine a long term test result is available with specific chemical analysis which is used for the hazard assessment because the results can be used for the bulk approach where the sorption to glassware was minimal and solution stability much better.
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