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Short-term toxicity to fish

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Description of key information

Only a limit number of short-term toxicity to fish studies are available for the substances under consideration. Therefore the test results of a number of alkyl-1,3-diaminopropanes and for dodecyltriamine Y were added to the dossier. Tri- and tetramines contain respectively about 22 – 11% diamines and for this reason the data for the diamines was added to the overview.  
It is considered reasonable to add dodecyltriamine Y as a worst-case as this substance is similar as the linear triamine andconsidered a the most toxic triamine. Dodecyltriamine Y is therefore selected as the Key study as this study is a Klimisch 1. The LC50 of this study is therefore used as the Key value for chemical safety assessment as a reasonable worst-case. In the final risk assessment this value will not be critical as two chronic end points are available.

Key value for chemical safety assessment

Fresh water fish

Fresh water fish
Effect concentration:
0.431 mg/L

Additional information

Most of the short-term toxicity fish tests were conducted in a period when no reliable specific method of analyses was available. The concentrations were therefore not analytically verified, the reliability of the results is limited because of the poor solubility of the test substances and partial sorption onto the walls of test vessels. Hence, most of the tests were considered to be valid with restrictions. Only one acute fish test study is available for N-(3-aminopropyl)-N-dodecylpropane-1,3-diamine (2372-82-9; dodecyltriamine Y) which is used as a biocide and this substance is considered as the most ecotoxic substance for the alkyl polyamines (>2N).The observed LC50 for this substance of 0.43 mg/L, suggests that the alkyl-1,3-diaminopropanes (2N) are more ecotoxic than the alkyl polyamines (>2N). Tri- and tetramines contain respectively about 22 – 11% diamines and for this reason the data for the diamines was added to the overview. 

For oleyl tetramine (4N) an LC50 (96 h) has been observed of 0.13 mg/L. This value is slightly lower than the value observed for dodecyltriamine Y. In the presence of humic acid however the toxicity of oleyl tetramine is reduced to an LC50 (96 h) of 2.01 mg/L demonstrating that under environmental conditions the toxicity is significantly reduced by river water constituents.