Registration Dossier
Registration Dossier
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EC number: 259-943-3 | CAS number: 56011-02-0
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 8 March to 24 April 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- no
Test material
- Reference substance name:
- Isopentyl phenethyl ether
- EC Number:
- 259-943-3
- EC Name:
- Isopentyl phenethyl ether
- Cas Number:
- 56011-02-0
- Molecular formula:
- C13H20O
- IUPAC Name:
- isopentyl phenethyl ether
Constituent 1
- Specific details on test material used for the study:
- Test material name (as stated in the report): ANTHER
Appearance: Clear colourless liquid
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- Rabbits aged of 9 - 12 weeks are used for each test. The whole dorsal surface is clipped 3 - 4 days before the test is due to start, and animals in the telogen phase of hair growth are selected.
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent positive control
- yes, concurrent negative control
- Amount / concentration applied:
- 0.5 ml of test material undiluted
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24, 48 and 72 hours
- Number of animals:
- 8 animals
- Details on study design:
- The test materials and appropriate standards are applied to the clipped dorsum of rabbits for 4 hours under individual semi-occlusive patches. After removal of the patches, the treated areas were wiped and examined for evidence of irritation. Further assessment are made 24, 48 and 72 hours after treatment, and occasionally up to 7 days fater treatment.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: 338, 328, 329, 307, 346, 332 and 316
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- erythema score
- Basis:
- animal: 335
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal: 338 and 332
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal: 328, 307 and 316
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal: 329 and 346
- Time point:
- 24/48/72 h
- Score:
- 1.66
- Max. score:
- 2
- Reversibility:
- not specified
- Irritation parameter:
- edema score
- Basis:
- animal: 335
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 1
- Reversibility:
- not specified
Any other information on results incl. tables
Anther showed mainly effects 24 and 72 hours after treatment. This response was similiar to the control Geraniol.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 (mild irritant) based on GHS criteria
- Conclusions:
- The test substance ANTHER was determined to be moderate irritatnt to skin in this test conditions.Neverthless ANTHER does not meet the criteria to be classified according to the CLP Regulation 1272/2008/EC.
- Executive summary:
The Anther was examined for skin irritation potentia in this Rabbit covered patch skin irritation test dated on 24 April 1982, performed at Unilever research Laboratory.
0.5 ml of test material are applied to the clipped dorsum of the rabbits for 4 hours under a semi occlusive patch. The irritation reactions are assessed immediately after removal of the patch and after 24, 48 and 72 hours. Anther showed mainly effects 24 and 72 hours after treatment. This response was similiar to the control Geraniol.
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